Anti-MMEL1/ MMEL2/ NEP2 monoclonal antibody

Anti-MMEL1/ MMEL2/ NEP2 antibody for FACS & in-vivo assay

Target products collectionGo to MMEL1/MMEL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0818-Ab-1/ GM-Tg-hg-MP0818-Ab-2Anti-Human MMEL1 monoclonal antibodyHuman
GM-Tg-rg-MP0818-Ab-1/ GM-Tg-rg-MP0818-Ab-2Anti-Rat MMEL1 monoclonal antibodyRat
GM-Tg-mg-MP0818-Ab-1/ GM-Tg-mg-MP0818-Ab-2Anti-Mouse MMEL1 monoclonal antibodyMouse
GM-Tg-cynog-MP0818-Ab-1/ GM-Tg-cynog-MP0818-Ab-2Anti-Cynomolgus/ Rhesus macaque MMEL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0818-Ab-1/ GM-Tg-felg-MP0818-Ab-2Anti-Feline MMEL1 monoclonal antibodyFeline
GM-Tg-cang-MP0818-Ab-1/ GM-Tg-cang-MP0818-Ab-2Anti-Canine MMEL1 monoclonal antibodyCanine
GM-Tg-bovg-MP0818-Ab-1/ GM-Tg-bovg-MP0818-Ab-2Anti-Bovine MMEL1 monoclonal antibodyBovine
GM-Tg-equg-MP0818-Ab-1/ GM-Tg-equg-MP0818-Ab-2Anti-Equine MMEL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0818-Ab-1/ GM-Tg-hg-MP0818-Ab-2; GM-Tg-rg-MP0818-Ab-1/ GM-Tg-rg-MP0818-Ab-2;
GM-Tg-mg-MP0818-Ab-1/ GM-Tg-mg-MP0818-Ab-2; GM-Tg-cynog-MP0818-Ab-1/ GM-Tg-cynog-MP0818-Ab-2;
GM-Tg-felg-MP0818-Ab-1/ GM-Tg-felg-MP0818-Ab-2; GM-Tg-cang-MP0818-Ab-1/ GM-Tg-cang-MP0818-Ab-2;
GM-Tg-bovg-MP0818-Ab-1/ GM-Tg-bovg-MP0818-Ab-2; GM-Tg-equg-MP0818-Ab-1/ GM-Tg-equg-MP0818-Ab-2
Products NameAnti-MMEL1 monoclonal antibody
Formatmab
Target NameMMEL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MMEL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MMEL1/ MMEL2/ NEP2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0818
    Target NameMMEL1
    Gene ID79258,27390,313755,698525,489617,101090372,616991,100054362
    Gene Symbol and SynonymsMell1,MMEL1,MMEL2,NEP2,NEP2(m),NEPII,NL-1,NL1,NL2,SEP
    Uniprot AccessionQ495T6,P0C1T0
    Uniprot Entry NameMMEL1_HUMAN,MMEL1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000142606
    Target ClassificationN/A

    The target: MMEL1, gene name: MMEL1, also named as MMEL2, NEP2, NEPII, NL1, NL2, SEP. The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.