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Anti-MYP0/ MPZ/ CHM monoclonal antibody
Anti-MYP0/ MPZ/ CHM antibody for FACS & in-vivo assay
Go to MPZ/MPZ products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0823-Ab-1/ GM-Tg-hg-MP0823-Ab-2 | Anti-Human MPZ monoclonal antibody | Human |
| GM-Tg-rg-MP0823-Ab-1/ GM-Tg-rg-MP0823-Ab-2 | Anti-Rat MPZ monoclonal antibody | Rat |
| GM-Tg-mg-MP0823-Ab-1/ GM-Tg-mg-MP0823-Ab-2 | Anti-Mouse MPZ monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0823-Ab-1/ GM-Tg-cynog-MP0823-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MPZ monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0823-Ab-1/ GM-Tg-felg-MP0823-Ab-2 | Anti-Feline MPZ monoclonal antibody | Feline |
| GM-Tg-cang-MP0823-Ab-1/ GM-Tg-cang-MP0823-Ab-2 | Anti-Canine MPZ monoclonal antibody | Canine |
| GM-Tg-bovg-MP0823-Ab-1/ GM-Tg-bovg-MP0823-Ab-2 | Anti-Bovine MPZ monoclonal antibody | Bovine |
| GM-Tg-equg-MP0823-Ab-1/ GM-Tg-equg-MP0823-Ab-2 | Anti-Equine MPZ monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0823-Ab-1/ GM-Tg-hg-MP0823-Ab-2; GM-Tg-rg-MP0823-Ab-1/ GM-Tg-rg-MP0823-Ab-2; GM-Tg-mg-MP0823-Ab-1/ GM-Tg-mg-MP0823-Ab-2; GM-Tg-cynog-MP0823-Ab-1/ GM-Tg-cynog-MP0823-Ab-2; GM-Tg-felg-MP0823-Ab-1/ GM-Tg-felg-MP0823-Ab-2; GM-Tg-cang-MP0823-Ab-1/ GM-Tg-cang-MP0823-Ab-2; GM-Tg-bovg-MP0823-Ab-1/ GM-Tg-bovg-MP0823-Ab-2; GM-Tg-equg-MP0823-Ab-1/ GM-Tg-equg-MP0823-Ab-2 |
| Products Name | Anti-MPZ monoclonal antibody |
| Format | mab |
| Target Name | MPZ |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MPZ benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MYP0/ MPZ/ CHM VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004500 | human MPZ Lentivirus plasmid |
| ORF Viral Vector | vGMLP004500 | human MPZ Lentivirus particle |
Target information
| Target ID | GM-MP0823 |
| Target Name | MPZ |
| Gene ID | 4359,17528,24564,719969,488654,101088210,539462,100034024 |
| Gene Symbol and Synonyms | CHM,CHN2,CMT1,CMT1B,CMT2I,CMT2J,CMT4E,CMTDI3,CMTDID,DSS,HMSNIB,MPP,MPZ,P-zero,P0 |
| Uniprot Accession | P25189,P06907,P10522,Q6WEB5 |
| Uniprot Entry Name | MYP0_HUMAN,MYP0_RAT,MYP0_BOVIN,MYP0_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000158887 |
| Target Classification | N/A |
The target: MPZ, gene name: MPZ, also named as CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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