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Anti-M4A12/ MS4A12/ Ms4a10 monoclonal antibody
Anti-M4A12/ MS4A12/ Ms4a10 antibody for FACS & in-vivo assay
Go to MS4A12/MS4A12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0837-Ab-1/ GM-Tg-hg-MP0837-Ab-2 | Anti-Human MS4A12 monoclonal antibody | Human |
| GM-Tg-rg-MP0837-Ab-1/ GM-Tg-rg-MP0837-Ab-2 | Anti-Rat MS4A12 monoclonal antibody | Rat |
| GM-Tg-mg-MP0837-Ab-1/ GM-Tg-mg-MP0837-Ab-2 | Anti-Mouse MS4A12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0837-Ab-1/ GM-Tg-cynog-MP0837-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MS4A12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0837-Ab-1/ GM-Tg-felg-MP0837-Ab-2 | Anti-Feline MS4A12 monoclonal antibody | Feline |
| GM-Tg-cang-MP0837-Ab-1/ GM-Tg-cang-MP0837-Ab-2 | Anti-Canine MS4A12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0837-Ab-1/ GM-Tg-bovg-MP0837-Ab-2 | Anti-Bovine MS4A12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0837-Ab-1/ GM-Tg-equg-MP0837-Ab-2 | Anti-Equine MS4A12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0837-Ab-1/ GM-Tg-hg-MP0837-Ab-2; GM-Tg-rg-MP0837-Ab-1/ GM-Tg-rg-MP0837-Ab-2; GM-Tg-mg-MP0837-Ab-1/ GM-Tg-mg-MP0837-Ab-2; GM-Tg-cynog-MP0837-Ab-1/ GM-Tg-cynog-MP0837-Ab-2; GM-Tg-felg-MP0837-Ab-1/ GM-Tg-felg-MP0837-Ab-2; GM-Tg-cang-MP0837-Ab-1/ GM-Tg-cang-MP0837-Ab-2; GM-Tg-bovg-MP0837-Ab-1/ GM-Tg-bovg-MP0837-Ab-2; GM-Tg-equg-MP0837-Ab-1/ GM-Tg-equg-MP0837-Ab-2 |
| Products Name | Anti-MS4A12 monoclonal antibody |
| Format | mab |
| Target Name | MS4A12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MS4A12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species M4A12/ MS4A12/ Ms4a10 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0837 |
| Target Name | MS4A12 |
| Gene ID | 54860,381213,293741,697777,101101668,100061613 |
| Gene Symbol and Synonyms | Gm966,Ms4a10,MS4A12 |
| Uniprot Accession | Q9NXJ0 |
| Uniprot Entry Name | M4A12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000071203 |
| Target Classification | N/A |
The target: MS4A12, gene name: MS4A12, also named as Ms4a10. The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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