Anti-M4A8/ MS4A8/ 4SPAN4 monoclonal antibody

Anti-M4A8/ MS4A8/ 4SPAN4 antibody for FACS & in-vivo assay

Target products collectionGo to MS4A8/MS4A8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0850-Ab-1/ GM-Tg-hg-MP0850-Ab-2Anti-Human MS4A8 monoclonal antibodyHuman
GM-Tg-rg-MP0850-Ab-1/ GM-Tg-rg-MP0850-Ab-2Anti-Rat MS4A8 monoclonal antibodyRat
GM-Tg-mg-MP0850-Ab-1/ GM-Tg-mg-MP0850-Ab-2Anti-Mouse MS4A8 monoclonal antibodyMouse
GM-Tg-cynog-MP0850-Ab-1/ GM-Tg-cynog-MP0850-Ab-2Anti-Cynomolgus/ Rhesus macaque MS4A8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0850-Ab-1/ GM-Tg-felg-MP0850-Ab-2Anti-Feline MS4A8 monoclonal antibodyFeline
GM-Tg-cang-MP0850-Ab-1/ GM-Tg-cang-MP0850-Ab-2Anti-Canine MS4A8 monoclonal antibodyCanine
GM-Tg-bovg-MP0850-Ab-1/ GM-Tg-bovg-MP0850-Ab-2Anti-Bovine MS4A8 monoclonal antibodyBovine
GM-Tg-equg-MP0850-Ab-1/ GM-Tg-equg-MP0850-Ab-2Anti-Equine MS4A8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0850-Ab-1/ GM-Tg-hg-MP0850-Ab-2; GM-Tg-rg-MP0850-Ab-1/ GM-Tg-rg-MP0850-Ab-2;
GM-Tg-mg-MP0850-Ab-1/ GM-Tg-mg-MP0850-Ab-2; GM-Tg-cynog-MP0850-Ab-1/ GM-Tg-cynog-MP0850-Ab-2;
GM-Tg-felg-MP0850-Ab-1/ GM-Tg-felg-MP0850-Ab-2; GM-Tg-cang-MP0850-Ab-1/ GM-Tg-cang-MP0850-Ab-2;
GM-Tg-bovg-MP0850-Ab-1/ GM-Tg-bovg-MP0850-Ab-2; GM-Tg-equg-MP0850-Ab-1/ GM-Tg-equg-MP0850-Ab-2
Products NameAnti-MS4A8 monoclonal antibody
Formatmab
Target NameMS4A8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MS4A8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species M4A8/ MS4A8/ 4SPAN4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0850
    Target NameMS4A8
    Gene ID83661,64381,361733,696345,415111
    Gene Symbol and Synonyms2010004L09Rik,4SPAN4,CD20L5,MS4A4,MS4A8,Ms4a8a,MS4A8B
    Uniprot AccessionQ9BY19
    Uniprot Entry NameM4A8_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000166959
    Target ClassificationN/A

    The target: MS4A8, gene name: MS4A8, also named as 4SPAN4, CD20L5, MS4A4B, MS4A8. This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.