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Anti-MUC12/ MUC-11/ MUC-12 monoclonal antibody
Anti-MUC12/ MUC-11/ MUC-12 antibody for FACS & in-vivo assay
Go to MUC12/MUC12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0853-Ab-1/ GM-Tg-hg-MP0853-Ab-2 | Anti-Human MUC12 monoclonal antibody | Human |
| GM-Tg-rg-MP0853-Ab-1/ GM-Tg-rg-MP0853-Ab-2 | Anti-Rat MUC12 monoclonal antibody | Rat |
| GM-Tg-mg-MP0853-Ab-1/ GM-Tg-mg-MP0853-Ab-2 | Anti-Mouse MUC12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0853-Ab-1/ GM-Tg-cynog-MP0853-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MUC12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0853-Ab-1/ GM-Tg-felg-MP0853-Ab-2 | Anti-Feline MUC12 monoclonal antibody | Feline |
| GM-Tg-cang-MP0853-Ab-1/ GM-Tg-cang-MP0853-Ab-2 | Anti-Canine MUC12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0853-Ab-1/ GM-Tg-bovg-MP0853-Ab-2 | Anti-Bovine MUC12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0853-Ab-1/ GM-Tg-equg-MP0853-Ab-2 | Anti-Equine MUC12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0853-Ab-1/ GM-Tg-hg-MP0853-Ab-2; GM-Tg-rg-MP0853-Ab-1/ GM-Tg-rg-MP0853-Ab-2; GM-Tg-mg-MP0853-Ab-1/ GM-Tg-mg-MP0853-Ab-2; GM-Tg-cynog-MP0853-Ab-1/ GM-Tg-cynog-MP0853-Ab-2; GM-Tg-felg-MP0853-Ab-1/ GM-Tg-felg-MP0853-Ab-2; GM-Tg-cang-MP0853-Ab-1/ GM-Tg-cang-MP0853-Ab-2; GM-Tg-bovg-MP0853-Ab-1/ GM-Tg-bovg-MP0853-Ab-2; GM-Tg-equg-MP0853-Ab-1/ GM-Tg-equg-MP0853-Ab-2 |
| Products Name | Anti-MUC12 monoclonal antibody |
| Format | mab |
| Target Name | MUC12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MUC12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MUC12/ MUC-11/ MUC-12 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0853 |
| Target Name | MUC12 |
| Gene ID | 10071,719516,123382665,106781522 |
| Gene Symbol and Synonyms | MUC-11,MUC-12,MUC11,MUC12 |
| Uniprot Accession | Q9UKN1 |
| Uniprot Entry Name | MUC12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000205277 |
| Target Classification | N/A |
The target: MUC12, gene name: MUC12, also named as MUC-11, MUC-12, MUC11. This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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