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Anti-MUC4/ ASGP/ HSA276359 monoclonal antibody
Anti-MUC4/ ASGP/ HSA276359 antibody for FACS & in-vivo assay
Go to MUC4/MUC4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0857-Ab-1/ GM-Tg-hg-MP0857-Ab-2 | Anti-Human MUC4 monoclonal antibody | Human |
| GM-Tg-rg-MP0857-Ab-1/ GM-Tg-rg-MP0857-Ab-2 | Anti-Rat MUC4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0857-Ab-1/ GM-Tg-mg-MP0857-Ab-2 | Anti-Mouse MUC4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0857-Ab-1/ GM-Tg-cynog-MP0857-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MUC4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0857-Ab-1/ GM-Tg-felg-MP0857-Ab-2 | Anti-Feline MUC4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0857-Ab-1/ GM-Tg-cang-MP0857-Ab-2 | Anti-Canine MUC4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0857-Ab-1/ GM-Tg-bovg-MP0857-Ab-2 | Anti-Bovine MUC4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0857-Ab-1/ GM-Tg-equg-MP0857-Ab-2 | Anti-Equine MUC4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0857-Ab-1/ GM-Tg-hg-MP0857-Ab-2; GM-Tg-rg-MP0857-Ab-1/ GM-Tg-rg-MP0857-Ab-2; GM-Tg-mg-MP0857-Ab-1/ GM-Tg-mg-MP0857-Ab-2; GM-Tg-cynog-MP0857-Ab-1/ GM-Tg-cynog-MP0857-Ab-2; GM-Tg-felg-MP0857-Ab-1/ GM-Tg-felg-MP0857-Ab-2; GM-Tg-cang-MP0857-Ab-1/ GM-Tg-cang-MP0857-Ab-2; GM-Tg-bovg-MP0857-Ab-1/ GM-Tg-bovg-MP0857-Ab-2; GM-Tg-equg-MP0857-Ab-1/ GM-Tg-equg-MP0857-Ab-2 |
| Products Name | Anti-MUC4 monoclonal antibody |
| Format | mab |
| Target Name | MUC4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MUC4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MUC4/ ASGP/ HSA276359 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0857 |
| Target Name | MUC4 |
| Gene ID | 4585,140474,303887,713146,488024,101081074,786701 |
| Gene Symbol and Synonyms | 4933405I11Rik,ASGP,ASGP-1,HSA276359,MUC-4,MUC4,Psmc |
| Uniprot Accession | Q99102,Q63661 |
| Uniprot Entry Name | MUC4_HUMAN,MUC4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000145113 |
| Target Classification | N/A |
The target: MUC4, gene name: MUC4, also named as ASGP, HSA276359, MUC-4. The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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