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Anti-MYOF/ FER1L3 monoclonal antibody
Anti-MYOF/ FER1L3 antibody for FACS & in-vivo assay
Go to MYOF/MYOF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0861-Ab-1/ GM-Tg-hg-MP0861-Ab-2 | Anti-Human MYOF monoclonal antibody | Human |
| GM-Tg-rg-MP0861-Ab-1/ GM-Tg-rg-MP0861-Ab-2 | Anti-Rat MYOF monoclonal antibody | Rat |
| GM-Tg-mg-MP0861-Ab-1/ GM-Tg-mg-MP0861-Ab-2 | Anti-Mouse MYOF monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0861-Ab-1/ GM-Tg-cynog-MP0861-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MYOF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0861-Ab-1/ GM-Tg-felg-MP0861-Ab-2 | Anti-Feline MYOF monoclonal antibody | Feline |
| GM-Tg-cang-MP0861-Ab-1/ GM-Tg-cang-MP0861-Ab-2 | Anti-Canine MYOF monoclonal antibody | Canine |
| GM-Tg-bovg-MP0861-Ab-1/ GM-Tg-bovg-MP0861-Ab-2 | Anti-Bovine MYOF monoclonal antibody | Bovine |
| GM-Tg-equg-MP0861-Ab-1/ GM-Tg-equg-MP0861-Ab-2 | Anti-Equine MYOF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0861-Ab-1/ GM-Tg-hg-MP0861-Ab-2; GM-Tg-rg-MP0861-Ab-1/ GM-Tg-rg-MP0861-Ab-2; GM-Tg-mg-MP0861-Ab-1/ GM-Tg-mg-MP0861-Ab-2; GM-Tg-cynog-MP0861-Ab-1/ GM-Tg-cynog-MP0861-Ab-2; GM-Tg-felg-MP0861-Ab-1/ GM-Tg-felg-MP0861-Ab-2; GM-Tg-cang-MP0861-Ab-1/ GM-Tg-cang-MP0861-Ab-2; GM-Tg-bovg-MP0861-Ab-1/ GM-Tg-bovg-MP0861-Ab-2; GM-Tg-equg-MP0861-Ab-1/ GM-Tg-equg-MP0861-Ab-2 |
| Products Name | Anti-MYOF monoclonal antibody |
| Format | mab |
| Target Name | MYOF |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MYOF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MYOF/ FER1L3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0861 |
| Target Name | MYOF |
| Gene ID | 26509,226101,309499,700922,607472,101087102,513597,100071199 |
| Gene Symbol and Synonyms | 2310004N10Rik,2310051D19Rik,E030042N20Rik,FER1L3,HAE7,MYOF,RGD1564216 |
| Uniprot Accession | Q9NZM1 |
| Uniprot Entry Name | MYOF_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000138119 |
| Target Classification | N/A |
The target: MYOF, gene name: MYOF, also named as FER1L3. Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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