Anti-NCKPL/ NCKAP1L/ HEM1 monoclonal antibody

Anti-NCKPL/ NCKAP1L/ HEM1 antibody for FACS & in-vivo assay

Target products collectionGo to NCKAP1L/NCKAP1L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0867-Ab-1/ GM-Tg-hg-MP0867-Ab-2Anti-Human NCKAP1L monoclonal antibodyHuman
GM-Tg-rg-MP0867-Ab-1/ GM-Tg-rg-MP0867-Ab-2Anti-Rat NCKAP1L monoclonal antibodyRat
GM-Tg-mg-MP0867-Ab-1/ GM-Tg-mg-MP0867-Ab-2Anti-Mouse NCKAP1L monoclonal antibodyMouse
GM-Tg-cynog-MP0867-Ab-1/ GM-Tg-cynog-MP0867-Ab-2Anti-Cynomolgus/ Rhesus macaque NCKAP1L monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0867-Ab-1/ GM-Tg-felg-MP0867-Ab-2Anti-Feline NCKAP1L monoclonal antibodyFeline
GM-Tg-cang-MP0867-Ab-1/ GM-Tg-cang-MP0867-Ab-2Anti-Canine NCKAP1L monoclonal antibodyCanine
GM-Tg-bovg-MP0867-Ab-1/ GM-Tg-bovg-MP0867-Ab-2Anti-Bovine NCKAP1L monoclonal antibodyBovine
GM-Tg-equg-MP0867-Ab-1/ GM-Tg-equg-MP0867-Ab-2Anti-Equine NCKAP1L monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0867-Ab-1/ GM-Tg-hg-MP0867-Ab-2; GM-Tg-rg-MP0867-Ab-1/ GM-Tg-rg-MP0867-Ab-2;
GM-Tg-mg-MP0867-Ab-1/ GM-Tg-mg-MP0867-Ab-2; GM-Tg-cynog-MP0867-Ab-1/ GM-Tg-cynog-MP0867-Ab-2;
GM-Tg-felg-MP0867-Ab-1/ GM-Tg-felg-MP0867-Ab-2; GM-Tg-cang-MP0867-Ab-1/ GM-Tg-cang-MP0867-Ab-2;
GM-Tg-bovg-MP0867-Ab-1/ GM-Tg-bovg-MP0867-Ab-2; GM-Tg-equg-MP0867-Ab-1/ GM-Tg-equg-MP0867-Ab-2
Products NameAnti-NCKAP1L monoclonal antibody
Formatmab
Target NameNCKAP1L
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NCKAP1L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NCKPL/ NCKAP1L/ HEM1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0867
    Target NameNCKAP1L
    Gene ID3071,105855,315348,705782,486492,101094357,513641,100062541
    Gene Symbol and Synonyms4930568P13Rik,HEM1,Hemp1,IMD72,NCKAP1L
    Uniprot AccessionP55160
    Uniprot Entry NameNCKPL_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000123338
    Target ClassificationN/A

    The target: NCKAP1L, gene name: NCKAP1L, also named as HEM1. This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.