Anti-NCTR3/ NCR3/ 1C7 monoclonal antibody

Anti-NCTR3/ NCR3/ 1C7 antibody for FACS & in-vivo assay

Target products collectionGo to NCR3/NCR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0869-Ab-1/ GM-Tg-hg-MP0869-Ab-2Anti-Human NCR3 monoclonal antibodyHuman
GM-Tg-rg-MP0869-Ab-1/ GM-Tg-rg-MP0869-Ab-2Anti-Rat NCR3 monoclonal antibodyRat
GM-Tg-mg-MP0869-Ab-1/ GM-Tg-mg-MP0869-Ab-2Anti-Mouse NCR3 monoclonal antibodyMouse
GM-Tg-cynog-MP0869-Ab-1/ GM-Tg-cynog-MP0869-Ab-2Anti-Cynomolgus/ Rhesus macaque NCR3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0869-Ab-1/ GM-Tg-felg-MP0869-Ab-2Anti-Feline NCR3 monoclonal antibodyFeline
GM-Tg-cang-MP0869-Ab-1/ GM-Tg-cang-MP0869-Ab-2Anti-Canine NCR3 monoclonal antibodyCanine
GM-Tg-bovg-MP0869-Ab-1/ GM-Tg-bovg-MP0869-Ab-2Anti-Bovine NCR3 monoclonal antibodyBovine
GM-Tg-equg-MP0869-Ab-1/ GM-Tg-equg-MP0869-Ab-2Anti-Equine NCR3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0869-Ab-1/ GM-Tg-hg-MP0869-Ab-2; GM-Tg-rg-MP0869-Ab-1/ GM-Tg-rg-MP0869-Ab-2;
GM-Tg-mg-MP0869-Ab-1/ GM-Tg-mg-MP0869-Ab-2; GM-Tg-cynog-MP0869-Ab-1/ GM-Tg-cynog-MP0869-Ab-2;
GM-Tg-felg-MP0869-Ab-1/ GM-Tg-felg-MP0869-Ab-2; GM-Tg-cang-MP0869-Ab-1/ GM-Tg-cang-MP0869-Ab-2;
GM-Tg-bovg-MP0869-Ab-1/ GM-Tg-bovg-MP0869-Ab-2; GM-Tg-equg-MP0869-Ab-1/ GM-Tg-equg-MP0869-Ab-2
Products NameAnti-NCR3 monoclonal antibody
Formatmab
Target NameNCR3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NCR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NCTR3/ NCR3/ 1C7 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP000063human NCR3 Lentivirus plasmid
    ORF Viral VectorvGMLP000063human NCR3 Lentivirus particle


    Target information

    Target IDGM-MP0869
    Target NameNCR3
    Gene ID259197,294251,715574,607220,101100052,513769,100058447
    Gene Symbol and Synonyms1C7,CD337,LY117,MALS,NCR3,NKp30
    Uniprot AccessionO14931,Q8CFD9,Q8MJ02
    Uniprot Entry NameNCTR3_HUMAN,NCTR3_MACMU,NCTR3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000204475
    Target ClassificationN/A

    The target: NCR3, gene name: NCR3, also named as 1C7, CD337, LY117, MALS, NKp30. The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.