Anti-NEO1/ IGDCC2/ NGN monoclonal antibody

Anti-NEO1/ IGDCC2/ NGN antibody for FACS & in-vivo assay

Target products collectionGo to NEO1/NEO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0873-Ab-1/ GM-Tg-hg-MP0873-Ab-2Anti-Human NEO1 monoclonal antibodyHuman
GM-Tg-rg-MP0873-Ab-1/ GM-Tg-rg-MP0873-Ab-2Anti-Rat NEO1 monoclonal antibodyRat
GM-Tg-mg-MP0873-Ab-1/ GM-Tg-mg-MP0873-Ab-2Anti-Mouse NEO1 monoclonal antibodyMouse
GM-Tg-cynog-MP0873-Ab-1/ GM-Tg-cynog-MP0873-Ab-2Anti-Cynomolgus/ Rhesus macaque NEO1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0873-Ab-1/ GM-Tg-felg-MP0873-Ab-2Anti-Feline NEO1 monoclonal antibodyFeline
GM-Tg-cang-MP0873-Ab-1/ GM-Tg-cang-MP0873-Ab-2Anti-Canine NEO1 monoclonal antibodyCanine
GM-Tg-bovg-MP0873-Ab-1/ GM-Tg-bovg-MP0873-Ab-2Anti-Bovine NEO1 monoclonal antibodyBovine
GM-Tg-equg-MP0873-Ab-1/ GM-Tg-equg-MP0873-Ab-2Anti-Equine NEO1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0873-Ab-1/ GM-Tg-hg-MP0873-Ab-2; GM-Tg-rg-MP0873-Ab-1/ GM-Tg-rg-MP0873-Ab-2;
GM-Tg-mg-MP0873-Ab-1/ GM-Tg-mg-MP0873-Ab-2; GM-Tg-cynog-MP0873-Ab-1/ GM-Tg-cynog-MP0873-Ab-2;
GM-Tg-felg-MP0873-Ab-1/ GM-Tg-felg-MP0873-Ab-2; GM-Tg-cang-MP0873-Ab-1/ GM-Tg-cang-MP0873-Ab-2;
GM-Tg-bovg-MP0873-Ab-1/ GM-Tg-bovg-MP0873-Ab-2; GM-Tg-equg-MP0873-Ab-1/ GM-Tg-equg-MP0873-Ab-2
Products NameAnti-NEO1 monoclonal antibody
Formatmab
Target NameNEO1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NEO1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NEO1/ IGDCC2/ NGN VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0873
    Target NameNEO1
    Gene ID4756,18007,81735,705160,487635,101090620,100297058,100063194
    Gene Symbol and Synonyms2610028H22Rik,D930014N22Rik,IGDCC2,NEO1,NGN,NTN1R2
    Uniprot AccessionQ92859,P97603
    Uniprot Entry NameNEO1_HUMAN,NEO1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000067141
    Target ClassificationN/A

    The target: NEO1, gene name: NEO1, also named as IGDCC2, NGN, NTN1R2. This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.