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Anti-NFASC/ NF/ NRCAML monoclonal antibody
Anti-NFASC/ NF/ NRCAML antibody for FACS & in-vivo assay
Go to NFASC/NFASC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0876-Ab-1/ GM-Tg-hg-MP0876-Ab-2 | Anti-Human NFASC monoclonal antibody | Human |
| GM-Tg-rg-MP0876-Ab-1/ GM-Tg-rg-MP0876-Ab-2 | Anti-Rat NFASC monoclonal antibody | Rat |
| GM-Tg-mg-MP0876-Ab-1/ GM-Tg-mg-MP0876-Ab-2 | Anti-Mouse NFASC monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0876-Ab-1/ GM-Tg-cynog-MP0876-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NFASC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0876-Ab-1/ GM-Tg-felg-MP0876-Ab-2 | Anti-Feline NFASC monoclonal antibody | Feline |
| GM-Tg-cang-MP0876-Ab-1/ GM-Tg-cang-MP0876-Ab-2 | Anti-Canine NFASC monoclonal antibody | Canine |
| GM-Tg-bovg-MP0876-Ab-1/ GM-Tg-bovg-MP0876-Ab-2 | Anti-Bovine NFASC monoclonal antibody | Bovine |
| GM-Tg-equg-MP0876-Ab-1/ GM-Tg-equg-MP0876-Ab-2 | Anti-Equine NFASC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0876-Ab-1/ GM-Tg-hg-MP0876-Ab-2; GM-Tg-rg-MP0876-Ab-1/ GM-Tg-rg-MP0876-Ab-2; GM-Tg-mg-MP0876-Ab-1/ GM-Tg-mg-MP0876-Ab-2; GM-Tg-cynog-MP0876-Ab-1/ GM-Tg-cynog-MP0876-Ab-2; GM-Tg-felg-MP0876-Ab-1/ GM-Tg-felg-MP0876-Ab-2; GM-Tg-cang-MP0876-Ab-1/ GM-Tg-cang-MP0876-Ab-2; GM-Tg-bovg-MP0876-Ab-1/ GM-Tg-bovg-MP0876-Ab-2; GM-Tg-equg-MP0876-Ab-1/ GM-Tg-equg-MP0876-Ab-2 |
| Products Name | Anti-NFASC monoclonal antibody |
| Format | mab |
| Target Name | NFASC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NFASC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NFASC/ NF/ NRCAML VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0876 |
| Target Name | NFASC |
| Gene ID | 23114,269116,116690,699444,488565,101083317,512796,100054575 |
| Gene Symbol and Synonyms | D430023G06Rik,mKIAA0756,NEDCPMD,NF,NFASC,NRCAML |
| Uniprot Accession | O94856,P97685 |
| Uniprot Entry Name | NFASC_HUMAN,NFASC_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000163531 |
| Target Classification | N/A |
The target: NFASC, gene name: NFASC, also named as NF, NRCAML. This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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