Anti-NLGNX/ NLGN4X/ ASPGX2 monoclonal antibody

Anti-NLGNX/ NLGN4X/ ASPGX2 antibody for FACS & in-vivo assay

Target products collectionGo to NLGN4X/NLGN4X products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0889-Ab-1/ GM-Tg-hg-MP0889-Ab-2Anti-Human NLGN4X monoclonal antibodyHuman
GM-Tg-rg-MP0889-Ab-1/ GM-Tg-rg-MP0889-Ab-2Anti-Rat NLGN4X monoclonal antibodyRat
GM-Tg-mg-MP0889-Ab-1/ GM-Tg-mg-MP0889-Ab-2Anti-Mouse NLGN4X monoclonal antibodyMouse
GM-Tg-cynog-MP0889-Ab-1/ GM-Tg-cynog-MP0889-Ab-2Anti-Cynomolgus/ Rhesus macaque NLGN4X monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0889-Ab-1/ GM-Tg-felg-MP0889-Ab-2Anti-Feline NLGN4X monoclonal antibodyFeline
GM-Tg-cang-MP0889-Ab-1/ GM-Tg-cang-MP0889-Ab-2Anti-Canine NLGN4X monoclonal antibodyCanine
GM-Tg-bovg-MP0889-Ab-1/ GM-Tg-bovg-MP0889-Ab-2Anti-Bovine NLGN4X monoclonal antibodyBovine
GM-Tg-equg-MP0889-Ab-1/ GM-Tg-equg-MP0889-Ab-2Anti-Equine NLGN4X monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0889-Ab-1/ GM-Tg-hg-MP0889-Ab-2; GM-Tg-rg-MP0889-Ab-1/ GM-Tg-rg-MP0889-Ab-2;
GM-Tg-mg-MP0889-Ab-1/ GM-Tg-mg-MP0889-Ab-2; GM-Tg-cynog-MP0889-Ab-1/ GM-Tg-cynog-MP0889-Ab-2;
GM-Tg-felg-MP0889-Ab-1/ GM-Tg-felg-MP0889-Ab-2; GM-Tg-cang-MP0889-Ab-1/ GM-Tg-cang-MP0889-Ab-2;
GM-Tg-bovg-MP0889-Ab-1/ GM-Tg-bovg-MP0889-Ab-2; GM-Tg-equg-MP0889-Ab-1/ GM-Tg-equg-MP0889-Ab-2
Products NameAnti-NLGN4X monoclonal antibody
Formatmab
Target NameNLGN4X
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NLGN4X benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NLGNX/ NLGN4X/ ASPGX2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0889
    Target NameNLGN4X
    Gene ID57502,106995148,607406,101082213,100300059,100050709
    Gene Symbol and SynonymsASPGX2,AUTSX2,HLNX,HNL4X,NLGN4,NLGN4X,NLGN4Y
    Uniprot AccessionQ8N0W4,Q8WMG7
    Uniprot Entry NameNLGNX_HUMAN,NLGNX_MACMU
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000146938
    Target ClassificationN/A

    The target: NLGN4X, gene name: NLGN4X, also named as ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4. This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.