Anti-NOX5 monoclonal antibody

Anti-NOX5 antibody for FACS & in-vivo assay

Target products collectionGo to NOX5/NOX5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0893-Ab-1/ GM-Tg-hg-MP0893-Ab-2Anti-Human NOX5 monoclonal antibodyHuman
GM-Tg-rg-MP0893-Ab-1/ GM-Tg-rg-MP0893-Ab-2Anti-Rat NOX5 monoclonal antibodyRat
GM-Tg-mg-MP0893-Ab-1/ GM-Tg-mg-MP0893-Ab-2Anti-Mouse NOX5 monoclonal antibodyMouse
GM-Tg-cynog-MP0893-Ab-1/ GM-Tg-cynog-MP0893-Ab-2Anti-Cynomolgus/ Rhesus macaque NOX5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0893-Ab-1/ GM-Tg-felg-MP0893-Ab-2Anti-Feline NOX5 monoclonal antibodyFeline
GM-Tg-cang-MP0893-Ab-1/ GM-Tg-cang-MP0893-Ab-2Anti-Canine NOX5 monoclonal antibodyCanine
GM-Tg-bovg-MP0893-Ab-1/ GM-Tg-bovg-MP0893-Ab-2Anti-Bovine NOX5 monoclonal antibodyBovine
GM-Tg-equg-MP0893-Ab-1/ GM-Tg-equg-MP0893-Ab-2Anti-Equine NOX5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0893-Ab-1/ GM-Tg-hg-MP0893-Ab-2; GM-Tg-rg-MP0893-Ab-1/ GM-Tg-rg-MP0893-Ab-2;
GM-Tg-mg-MP0893-Ab-1/ GM-Tg-mg-MP0893-Ab-2; GM-Tg-cynog-MP0893-Ab-1/ GM-Tg-cynog-MP0893-Ab-2;
GM-Tg-felg-MP0893-Ab-1/ GM-Tg-felg-MP0893-Ab-2; GM-Tg-cang-MP0893-Ab-1/ GM-Tg-cang-MP0893-Ab-2;
GM-Tg-bovg-MP0893-Ab-1/ GM-Tg-bovg-MP0893-Ab-2; GM-Tg-equg-MP0893-Ab-1/ GM-Tg-equg-MP0893-Ab-2
Products NameAnti-NOX5 monoclonal antibody
Formatmab
Target NameNOX5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NOX5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NOX5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0893
    Target NameNOX5
    Gene ID79400,694875,487620,101098957,531303,100034218
    Gene Symbol and SynonymsNOX5
    Uniprot AccessionQ96PH1
    Uniprot Entry NameNOX5_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000255346
    Target ClassificationN/A

    The target: NOX5, gene name: NOX5, also named as . This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.