Anti-NPBW2/ NPBWR2/ GPR8 monoclonal antibody

Anti-NPBW2/ NPBWR2/ GPR8 antibody for FACS & in-vivo assay

Target products collectionGo to NPBWR2/NPBWR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0895-Ab-1/ GM-Tg-hg-MP0895-Ab-2Anti-Human NPBWR2 monoclonal antibodyHuman
GM-Tg-rg-MP0895-Ab-1/ GM-Tg-rg-MP0895-Ab-2Anti-Rat NPBWR2 monoclonal antibodyRat
GM-Tg-mg-MP0895-Ab-1/ GM-Tg-mg-MP0895-Ab-2Anti-Mouse NPBWR2 monoclonal antibodyMouse
GM-Tg-cynog-MP0895-Ab-1/ GM-Tg-cynog-MP0895-Ab-2Anti-Cynomolgus/ Rhesus macaque NPBWR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0895-Ab-1/ GM-Tg-felg-MP0895-Ab-2Anti-Feline NPBWR2 monoclonal antibodyFeline
GM-Tg-cang-MP0895-Ab-1/ GM-Tg-cang-MP0895-Ab-2Anti-Canine NPBWR2 monoclonal antibodyCanine
GM-Tg-bovg-MP0895-Ab-1/ GM-Tg-bovg-MP0895-Ab-2Anti-Bovine NPBWR2 monoclonal antibodyBovine
GM-Tg-equg-MP0895-Ab-1/ GM-Tg-equg-MP0895-Ab-2Anti-Equine NPBWR2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0895-Ab-1/ GM-Tg-hg-MP0895-Ab-2; GM-Tg-rg-MP0895-Ab-1/ GM-Tg-rg-MP0895-Ab-2;
GM-Tg-mg-MP0895-Ab-1/ GM-Tg-mg-MP0895-Ab-2; GM-Tg-cynog-MP0895-Ab-1/ GM-Tg-cynog-MP0895-Ab-2;
GM-Tg-felg-MP0895-Ab-1/ GM-Tg-felg-MP0895-Ab-2; GM-Tg-cang-MP0895-Ab-1/ GM-Tg-cang-MP0895-Ab-2;
GM-Tg-bovg-MP0895-Ab-1/ GM-Tg-bovg-MP0895-Ab-2; GM-Tg-equg-MP0895-Ab-1/ GM-Tg-equg-MP0895-Ab-2
Products NameAnti-NPBWR2 monoclonal antibody
Formatmab
Target NameNPBWR2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NPBWR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NPBW2/ NPBWR2/ GPR8 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0895
    Target NameNPBWR2
    Gene ID2832,665538,719200,101094010,281208,100071567
    Gene Symbol and SynonymsGm14489,GPR8,NPBWR2
    Uniprot AccessionP48146,Q8MJV2
    Uniprot Entry NameNPBW2_HUMAN,NPBW2_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000125522
    Target ClassificationGPCR

    The target: NPBWR2, gene name: NPBWR2, also named as GPR8. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.