Anti-LRC33/ NRROS/ ELLP3030 monoclonal antibody

Anti-LRC33/ NRROS/ ELLP3030 antibody for FACS & in-vivo assay

Target products collectionGo to NRROS/NRROS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0906-Ab-1/ GM-Tg-hg-MP0906-Ab-2Anti-Human NRROS monoclonal antibodyHuman
GM-Tg-rg-MP0906-Ab-1/ GM-Tg-rg-MP0906-Ab-2Anti-Rat NRROS monoclonal antibodyRat
GM-Tg-mg-MP0906-Ab-1/ GM-Tg-mg-MP0906-Ab-2Anti-Mouse NRROS monoclonal antibodyMouse
GM-Tg-cynog-MP0906-Ab-1/ GM-Tg-cynog-MP0906-Ab-2Anti-Cynomolgus/ Rhesus macaque NRROS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0906-Ab-1/ GM-Tg-felg-MP0906-Ab-2Anti-Feline NRROS monoclonal antibodyFeline
GM-Tg-cang-MP0906-Ab-1/ GM-Tg-cang-MP0906-Ab-2Anti-Canine NRROS monoclonal antibodyCanine
GM-Tg-bovg-MP0906-Ab-1/ GM-Tg-bovg-MP0906-Ab-2Anti-Bovine NRROS monoclonal antibodyBovine
GM-Tg-equg-MP0906-Ab-1/ GM-Tg-equg-MP0906-Ab-2Anti-Equine NRROS monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0906-Ab-1/ GM-Tg-hg-MP0906-Ab-2; GM-Tg-rg-MP0906-Ab-1/ GM-Tg-rg-MP0906-Ab-2;
GM-Tg-mg-MP0906-Ab-1/ GM-Tg-mg-MP0906-Ab-2; GM-Tg-cynog-MP0906-Ab-1/ GM-Tg-cynog-MP0906-Ab-2;
GM-Tg-felg-MP0906-Ab-1/ GM-Tg-felg-MP0906-Ab-2; GM-Tg-cang-MP0906-Ab-1/ GM-Tg-cang-MP0906-Ab-2;
GM-Tg-bovg-MP0906-Ab-1/ GM-Tg-bovg-MP0906-Ab-2; GM-Tg-equg-MP0906-Ab-1/ GM-Tg-equg-MP0906-Ab-2
Products NameAnti-NRROS monoclonal antibody
Formatmab
Target NameNRROS
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NRROS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRC33/ NRROS/ ELLP3030 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0906
    Target NameNRROS
    Gene ID375387,224109,303875,710573,488032,101082086,510688,100069731
    Gene Symbol and SynonymsE430025L02Rik,ELLP3030,GARPL1,Lrcc33,LRRC33,NRROS,RGD1310771,SENEBAC,UNQ3030
    Uniprot AccessionQ86YC3,Q5BK65,Q3ZBI5
    Uniprot Entry NameLRC33_HUMAN,LRC33_RAT,LRC33_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000174004
    Target ClassificationN/A

    The target: NRROS, gene name: NRROS, also named as ELLP3030, GARPL1, LRRC33, UNQ3030. Enables transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.