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Anti-NRX1B/ NRX1A/ NRXN1 monoclonal antibody
Anti-NRX1B/ NRX1A/ NRXN1 antibody for FACS & in-vivo assay
Go to NRXN1/NRXN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0908-Ab-1/ GM-Tg-hg-MP0908-Ab-2 | Anti-Human NRXN1 monoclonal antibody | Human |
| GM-Tg-rg-MP0908-Ab-1/ GM-Tg-rg-MP0908-Ab-2 | Anti-Rat NRXN1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0908-Ab-1/ GM-Tg-mg-MP0908-Ab-2 | Anti-Mouse NRXN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0908-Ab-1/ GM-Tg-cynog-MP0908-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NRXN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0908-Ab-1/ GM-Tg-felg-MP0908-Ab-2 | Anti-Feline NRXN1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0908-Ab-1/ GM-Tg-cang-MP0908-Ab-2 | Anti-Canine NRXN1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0908-Ab-1/ GM-Tg-bovg-MP0908-Ab-2 | Anti-Bovine NRXN1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0908-Ab-1/ GM-Tg-equg-MP0908-Ab-2 | Anti-Equine NRXN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0908-Ab-1/ GM-Tg-hg-MP0908-Ab-2; GM-Tg-rg-MP0908-Ab-1/ GM-Tg-rg-MP0908-Ab-2; GM-Tg-mg-MP0908-Ab-1/ GM-Tg-mg-MP0908-Ab-2; GM-Tg-cynog-MP0908-Ab-1/ GM-Tg-cynog-MP0908-Ab-2; GM-Tg-felg-MP0908-Ab-1/ GM-Tg-felg-MP0908-Ab-2; GM-Tg-cang-MP0908-Ab-1/ GM-Tg-cang-MP0908-Ab-2; GM-Tg-bovg-MP0908-Ab-1/ GM-Tg-bovg-MP0908-Ab-2; GM-Tg-equg-MP0908-Ab-1/ GM-Tg-equg-MP0908-Ab-2 |
| Products Name | Anti-NRXN1 monoclonal antibody |
| Format | mab |
| Target Name | NRXN1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NRXN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NRX1B/ NRX1A/ NRXN1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0908 |
| Target Name | NRXN1 |
| Gene ID | 9378,18189,60391,619185,474589,101084531,281950,100052908 |
| Gene Symbol and Synonyms | 1700062G21Rik,9330127H16Rik,A230068P09Rik,Hs.22998,mKIAA0578,NRXN1,Nrxn1b,PTHSL2,SCZD17 |
| Uniprot Accession | P58400, Q9ULB1,Q63372,Q63373,Q28142,Q28146 |
| Uniprot Entry Name | NRX1A_HUMAN,NRX1A_RAT,NRX1B_RAT,NRX1B_BOVIN,NRX1A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000179915 |
| Target Classification | N/A |
The target: NRXN1, gene name: NRXN1, also named as Hs.22998, PTHSL2, SCZD17. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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