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Anti-NRX2B/ NRX2A/ NRXN2 monoclonal antibody
Anti-NRX2B/ NRX2A/ NRXN2 antibody for FACS & in-vivo assay
Go to NRXN2/NRXN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0909-Ab-1/ GM-Tg-hg-MP0909-Ab-2 | Anti-Human NRXN2 monoclonal antibody | Human |
| GM-Tg-rg-MP0909-Ab-1/ GM-Tg-rg-MP0909-Ab-2 | Anti-Rat NRXN2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0909-Ab-1/ GM-Tg-mg-MP0909-Ab-2 | Anti-Mouse NRXN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0909-Ab-1/ GM-Tg-cynog-MP0909-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NRXN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0909-Ab-1/ GM-Tg-felg-MP0909-Ab-2 | Anti-Feline NRXN2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0909-Ab-1/ GM-Tg-cang-MP0909-Ab-2 | Anti-Canine NRXN2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0909-Ab-1/ GM-Tg-bovg-MP0909-Ab-2 | Anti-Bovine NRXN2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0909-Ab-1/ GM-Tg-equg-MP0909-Ab-2 | Anti-Equine NRXN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0909-Ab-1/ GM-Tg-hg-MP0909-Ab-2; GM-Tg-rg-MP0909-Ab-1/ GM-Tg-rg-MP0909-Ab-2; GM-Tg-mg-MP0909-Ab-1/ GM-Tg-mg-MP0909-Ab-2; GM-Tg-cynog-MP0909-Ab-1/ GM-Tg-cynog-MP0909-Ab-2; GM-Tg-felg-MP0909-Ab-1/ GM-Tg-felg-MP0909-Ab-2; GM-Tg-cang-MP0909-Ab-1/ GM-Tg-cang-MP0909-Ab-2; GM-Tg-bovg-MP0909-Ab-1/ GM-Tg-bovg-MP0909-Ab-2; GM-Tg-equg-MP0909-Ab-1/ GM-Tg-equg-MP0909-Ab-2 |
| Products Name | Anti-NRXN2 monoclonal antibody |
| Format | mab |
| Target Name | NRXN2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NRXN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NRX2B/ NRX2A/ NRXN2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0909 |
| Target Name | NRXN2 |
| Gene ID | 9379,18190,116595,574175,101094207,537808,100055880 |
| Gene Symbol and Synonyms | 6430591O13Rik,mKIAA0921,NRXN2 |
| Uniprot Accession | P58401, Q9P2S2,Q63374,Q63376 |
| Uniprot Entry Name | NRX2A_HUMAN,NRX2A_RAT,NRX2B_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000110076 |
| Target Classification | N/A |
The target: NRXN2, gene name: NRXN2, also named as . This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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