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Anti-NRX3B/ NRX3A/ NRXN3 monoclonal antibody
Anti-NRX3B/ NRX3A/ NRXN3 antibody for FACS & in-vivo assay
Go to NRXN3/NRXN3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0910-Ab-1/ GM-Tg-hg-MP0910-Ab-2 | Anti-Human NRXN3 monoclonal antibody | Human |
| GM-Tg-rg-MP0910-Ab-1/ GM-Tg-rg-MP0910-Ab-2 | Anti-Rat NRXN3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0910-Ab-1/ GM-Tg-mg-MP0910-Ab-2 | Anti-Mouse NRXN3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0910-Ab-1/ GM-Tg-cynog-MP0910-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NRXN3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0910-Ab-1/ GM-Tg-felg-MP0910-Ab-2 | Anti-Feline NRXN3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0910-Ab-1/ GM-Tg-cang-MP0910-Ab-2 | Anti-Canine NRXN3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0910-Ab-1/ GM-Tg-bovg-MP0910-Ab-2 | Anti-Bovine NRXN3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0910-Ab-1/ GM-Tg-equg-MP0910-Ab-2 | Anti-Equine NRXN3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0910-Ab-1/ GM-Tg-hg-MP0910-Ab-2; GM-Tg-rg-MP0910-Ab-1/ GM-Tg-rg-MP0910-Ab-2; GM-Tg-mg-MP0910-Ab-1/ GM-Tg-mg-MP0910-Ab-2; GM-Tg-cynog-MP0910-Ab-1/ GM-Tg-cynog-MP0910-Ab-2; GM-Tg-felg-MP0910-Ab-1/ GM-Tg-felg-MP0910-Ab-2; GM-Tg-cang-MP0910-Ab-1/ GM-Tg-cang-MP0910-Ab-2; GM-Tg-bovg-MP0910-Ab-1/ GM-Tg-bovg-MP0910-Ab-2; GM-Tg-equg-MP0910-Ab-1/ GM-Tg-equg-MP0910-Ab-2 |
| Products Name | Anti-NRXN3 monoclonal antibody |
| Format | mab |
| Target Name | NRXN3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NRXN3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NRX3B/ NRX3A/ NRXN3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0910 |
| Target Name | NRXN3 |
| Gene ID | 9369,18191,116508,678699,490812,101087071,100059645 |
| Gene Symbol and Synonyms | C14orf60,NRXN3 |
| Uniprot Accession | Q9HDB5, Q9Y4C0,Q07310 |
| Uniprot Entry Name | NRX3A_HUMAN,NRX3A_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000021645 |
| Target Classification | N/A |
The target: NRXN3, gene name: NRXN3, also named as C14orf60. This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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