Anti-NET4/ NTN4/ PRO3091 monoclonal antibody

Anti-NET4/ NTN4/ PRO3091 antibody for FACS & in-vivo assay

Target products collectionGo to NTN4/NTN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0912-Ab-1/ GM-Tg-hg-MP0912-Ab-2Anti-Human NTN4 monoclonal antibodyHuman
GM-Tg-rg-MP0912-Ab-1/ GM-Tg-rg-MP0912-Ab-2Anti-Rat NTN4 monoclonal antibodyRat
GM-Tg-mg-MP0912-Ab-1/ GM-Tg-mg-MP0912-Ab-2Anti-Mouse NTN4 monoclonal antibodyMouse
GM-Tg-cynog-MP0912-Ab-1/ GM-Tg-cynog-MP0912-Ab-2Anti-Cynomolgus/ Rhesus macaque NTN4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0912-Ab-1/ GM-Tg-felg-MP0912-Ab-2Anti-Feline NTN4 monoclonal antibodyFeline
GM-Tg-cang-MP0912-Ab-1/ GM-Tg-cang-MP0912-Ab-2Anti-Canine NTN4 monoclonal antibodyCanine
GM-Tg-bovg-MP0912-Ab-1/ GM-Tg-bovg-MP0912-Ab-2Anti-Bovine NTN4 monoclonal antibodyBovine
GM-Tg-equg-MP0912-Ab-1/ GM-Tg-equg-MP0912-Ab-2Anti-Equine NTN4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0912-Ab-1/ GM-Tg-hg-MP0912-Ab-2; GM-Tg-rg-MP0912-Ab-1/ GM-Tg-rg-MP0912-Ab-2;
GM-Tg-mg-MP0912-Ab-1/ GM-Tg-mg-MP0912-Ab-2; GM-Tg-cynog-MP0912-Ab-1/ GM-Tg-cynog-MP0912-Ab-2;
GM-Tg-felg-MP0912-Ab-1/ GM-Tg-felg-MP0912-Ab-2; GM-Tg-cang-MP0912-Ab-1/ GM-Tg-cang-MP0912-Ab-2;
GM-Tg-bovg-MP0912-Ab-1/ GM-Tg-bovg-MP0912-Ab-2; GM-Tg-equg-MP0912-Ab-1/ GM-Tg-equg-MP0912-Ab-2
Products NameAnti-NTN4 monoclonal antibody
Formatmab
Target NameNTN4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NTN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NET4/ NTN4/ PRO3091 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0912
    Target NameNTN4
    Gene ID59277,57764,299737,712628,475431,101091542,537455,100065441
    Gene Symbol and SynonymsNTN4,PRO3091,RGD1565947
    Uniprot AccessionQ9HB63
    Uniprot Entry NameNET4_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000074527
    Target ClassificationN/A

    The target: NTN4, gene name: NTN4, also named as PRO3091. This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.