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Anti-OCLN/ BLCPMG/ PPP1R115 monoclonal antibody
Anti-OCLN/ BLCPMG/ PPP1R115 antibody for FACS & in-vivo assay
Go to OCLN/OCLN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0916-Ab-1/ GM-Tg-hg-MP0916-Ab-2 | Anti-Human OCLN monoclonal antibody | Human |
| GM-Tg-rg-MP0916-Ab-1/ GM-Tg-rg-MP0916-Ab-2 | Anti-Rat OCLN monoclonal antibody | Rat |
| GM-Tg-mg-MP0916-Ab-1/ GM-Tg-mg-MP0916-Ab-2 | Anti-Mouse OCLN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0916-Ab-1/ GM-Tg-cynog-MP0916-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OCLN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0916-Ab-1/ GM-Tg-felg-MP0916-Ab-2 | Anti-Feline OCLN monoclonal antibody | Feline |
| GM-Tg-cang-MP0916-Ab-1/ GM-Tg-cang-MP0916-Ab-2 | Anti-Canine OCLN monoclonal antibody | Canine |
| GM-Tg-bovg-MP0916-Ab-1/ GM-Tg-bovg-MP0916-Ab-2 | Anti-Bovine OCLN monoclonal antibody | Bovine |
| GM-Tg-equg-MP0916-Ab-1/ GM-Tg-equg-MP0916-Ab-2 | Anti-Equine OCLN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0916-Ab-1/ GM-Tg-hg-MP0916-Ab-2; GM-Tg-rg-MP0916-Ab-1/ GM-Tg-rg-MP0916-Ab-2; GM-Tg-mg-MP0916-Ab-1/ GM-Tg-mg-MP0916-Ab-2; GM-Tg-cynog-MP0916-Ab-1/ GM-Tg-cynog-MP0916-Ab-2; GM-Tg-felg-MP0916-Ab-1/ GM-Tg-felg-MP0916-Ab-2; GM-Tg-cang-MP0916-Ab-1/ GM-Tg-cang-MP0916-Ab-2; GM-Tg-bovg-MP0916-Ab-1/ GM-Tg-bovg-MP0916-Ab-2; GM-Tg-equg-MP0916-Ab-1/ GM-Tg-equg-MP0916-Ab-2 |
| Products Name | Anti-OCLN monoclonal antibody |
| Format | mab |
| Target Name | OCLN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OCLN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species OCLN/ BLCPMG/ PPP1R115 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001093 | human OCLN Lentivirus particle |
| ORF Viral Vector | pGMLP001093 | human OCLN Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005039 | mouse Ocln Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005039 | mouse Ocln Lentivirus particle |
Target information
| Target ID | GM-MP0916 |
| Target Name | OCLN |
| Gene ID | 100506658,18260,83497,700504,403844,101089577,512405,100073306 |
| Gene Symbol and Synonyms | BLCPMG,Ocl,OCLN,PPP1R115,PTORCH1 |
| Uniprot Accession | Q16625,Q6P6T5,Q28269 |
| Uniprot Entry Name | OCLN_HUMAN,OCLN_RAT,OCLN_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000197822 |
| Target Classification | N/A |
The target: OCLN, gene name: OCLN, also named as BLCPMG, PPP1R115, PTORCH1. This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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