Anti-OPCM/ OPCML/ IGLON1 monoclonal antibody

Anti-OPCM/ OPCML/ IGLON1 antibody for FACS & in-vivo assay

Target products collectionGo to OPCML/OPCML products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0920-Ab-1/ GM-Tg-hg-MP0920-Ab-2Anti-Human OPCML monoclonal antibodyHuman
GM-Tg-rg-MP0920-Ab-1/ GM-Tg-rg-MP0920-Ab-2Anti-Rat OPCML monoclonal antibodyRat
GM-Tg-mg-MP0920-Ab-1/ GM-Tg-mg-MP0920-Ab-2Anti-Mouse OPCML monoclonal antibodyMouse
GM-Tg-cynog-MP0920-Ab-1/ GM-Tg-cynog-MP0920-Ab-2Anti-Cynomolgus/ Rhesus macaque OPCML monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0920-Ab-1/ GM-Tg-felg-MP0920-Ab-2Anti-Feline OPCML monoclonal antibodyFeline
GM-Tg-cang-MP0920-Ab-1/ GM-Tg-cang-MP0920-Ab-2Anti-Canine OPCML monoclonal antibodyCanine
GM-Tg-bovg-MP0920-Ab-1/ GM-Tg-bovg-MP0920-Ab-2Anti-Bovine OPCML monoclonal antibodyBovine
GM-Tg-equg-MP0920-Ab-1/ GM-Tg-equg-MP0920-Ab-2Anti-Equine OPCML monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0920-Ab-1/ GM-Tg-hg-MP0920-Ab-2; GM-Tg-rg-MP0920-Ab-1/ GM-Tg-rg-MP0920-Ab-2;
GM-Tg-mg-MP0920-Ab-1/ GM-Tg-mg-MP0920-Ab-2; GM-Tg-cynog-MP0920-Ab-1/ GM-Tg-cynog-MP0920-Ab-2;
GM-Tg-felg-MP0920-Ab-1/ GM-Tg-felg-MP0920-Ab-2; GM-Tg-cang-MP0920-Ab-1/ GM-Tg-cang-MP0920-Ab-2;
GM-Tg-bovg-MP0920-Ab-1/ GM-Tg-bovg-MP0920-Ab-2; GM-Tg-equg-MP0920-Ab-1/ GM-Tg-equg-MP0920-Ab-2
Products NameAnti-OPCML monoclonal antibody
Formatmab
Target NameOPCML
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-OPCML benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species OPCM/ OPCML/ IGLON1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAAV000303house mouse Opcml AAV plasmid
    ORF Viral VectorpGMLPm003386mouse Opcml Lentivirus plasmid
    ORF Viral VectorvGMAAV000303house mouse Opcml AAV particle
    ORF Viral VectorvGMLPm003386mouse Opcml Lentivirus particle


    Target information

    Target IDGM-MP0920
    Target NameOPCML
    Gene ID4978,330908,116597,693404,100686219,101094787,100064790
    Gene Symbol and Synonyms2900075O15Rik,3732419F12,B930023M13Rik,C230027C17,Gm181,IGLON1,OBCAM,OPCM,OPCML
    Uniprot AccessionQ14982,P32736
    Uniprot Entry NameOPCM_HUMAN,OPCM_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseLung Cancer
    Gene EnsemblENSG00000183715
    Target ClassificationN/A

    The target: OPCML, gene name: OPCML, also named as IGLON1, OBCAM, OPCM. This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.