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Anti-OPN4/ MOP monoclonal antibody
Anti-OPN4/ MOP antibody for FACS & in-vivo assay
Go to OPN4/OPN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0925-Ab-1/ GM-Tg-hg-MP0925-Ab-2 | Anti-Human OPN4 monoclonal antibody | Human |
| GM-Tg-rg-MP0925-Ab-1/ GM-Tg-rg-MP0925-Ab-2 | Anti-Rat OPN4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0925-Ab-1/ GM-Tg-mg-MP0925-Ab-2 | Anti-Mouse OPN4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0925-Ab-1/ GM-Tg-cynog-MP0925-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OPN4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0925-Ab-1/ GM-Tg-felg-MP0925-Ab-2 | Anti-Feline OPN4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0925-Ab-1/ GM-Tg-cang-MP0925-Ab-2 | Anti-Canine OPN4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0925-Ab-1/ GM-Tg-bovg-MP0925-Ab-2 | Anti-Bovine OPN4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0925-Ab-1/ GM-Tg-equg-MP0925-Ab-2 | Anti-Equine OPN4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0925-Ab-1/ GM-Tg-hg-MP0925-Ab-2; GM-Tg-rg-MP0925-Ab-1/ GM-Tg-rg-MP0925-Ab-2; GM-Tg-mg-MP0925-Ab-1/ GM-Tg-mg-MP0925-Ab-2; GM-Tg-cynog-MP0925-Ab-1/ GM-Tg-cynog-MP0925-Ab-2; GM-Tg-felg-MP0925-Ab-1/ GM-Tg-felg-MP0925-Ab-2; GM-Tg-cang-MP0925-Ab-1/ GM-Tg-cang-MP0925-Ab-2; GM-Tg-bovg-MP0925-Ab-1/ GM-Tg-bovg-MP0925-Ab-2; GM-Tg-equg-MP0925-Ab-1/ GM-Tg-equg-MP0925-Ab-2 |
| Products Name | Anti-OPN4 monoclonal antibody |
| Format | mab |
| Target Name | OPN4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OPN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species OPN4/ MOP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004476 | mouse Opn4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004476 | mouse Opn4 Lentivirus particle |
Target information
| Target ID | GM-MP0925 |
| Target Name | OPN4 |
| Gene ID | 94233,30044,192223,699800,611027,493921,515152,100052462 |
| Gene Symbol and Synonyms | 1110007J02Rik,Gm533,MOP,OPN4,Opsin-4 |
| Uniprot Accession | Q9UHM6,Q8R456,Q5YKK9 |
| Uniprot Entry Name | OPN4_HUMAN,OPN4_RAT,OPN4_FELCA |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000122375 |
| Target Classification | N/A |
The target: OPN4, gene name: OPN4, also named as MOP. Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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