Anti-ORAI3/ ™EM142C monoclonal antibody

Anti-ORAI3/ ™EM142C antibody for FACS & in-vivo assay

Target products collectionGo to ORAI3/ORAI3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1302-Ab-1/ GM-Tg-hg-MP1302-Ab-2Anti-Human ORAI3 monoclonal antibodyHuman
GM-Tg-rg-MP1302-Ab-1/ GM-Tg-rg-MP1302-Ab-2Anti-Rat ORAI3 monoclonal antibodyRat
GM-Tg-mg-MP1302-Ab-1/ GM-Tg-mg-MP1302-Ab-2Anti-Mouse ORAI3 monoclonal antibodyMouse
GM-Tg-cynog-MP1302-Ab-1/ GM-Tg-cynog-MP1302-Ab-2Anti-Cynomolgus/ Rhesus macaque ORAI3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1302-Ab-1/ GM-Tg-felg-MP1302-Ab-2Anti-Feline ORAI3 monoclonal antibodyFeline
GM-Tg-cang-MP1302-Ab-1/ GM-Tg-cang-MP1302-Ab-2Anti-Canine ORAI3 monoclonal antibodyCanine
GM-Tg-bovg-MP1302-Ab-1/ GM-Tg-bovg-MP1302-Ab-2Anti-Bovine ORAI3 monoclonal antibodyBovine
GM-Tg-equg-MP1302-Ab-1/ GM-Tg-equg-MP1302-Ab-2Anti-Equine ORAI3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1302-Ab-1/ GM-Tg-hg-MP1302-Ab-2; GM-Tg-rg-MP1302-Ab-1/ GM-Tg-rg-MP1302-Ab-2;
GM-Tg-mg-MP1302-Ab-1/ GM-Tg-mg-MP1302-Ab-2; GM-Tg-cynog-MP1302-Ab-1/ GM-Tg-cynog-MP1302-Ab-2;
GM-Tg-felg-MP1302-Ab-1/ GM-Tg-felg-MP1302-Ab-2; GM-Tg-cang-MP1302-Ab-1/ GM-Tg-cang-MP1302-Ab-2;
GM-Tg-bovg-MP1302-Ab-1/ GM-Tg-bovg-MP1302-Ab-2; GM-Tg-equg-MP1302-Ab-1/ GM-Tg-equg-MP1302-Ab-2
Products NameAnti-ORAI3 monoclonal antibody
Formatmab
Target NameORAI3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ORAI3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ORAI3/ ™EM142C VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP003862human ORAI3 Lentivirus particle
    ORF Viral VectorpGMLP003862human ORAI3 Lentivirus plasmid


    Target information

    Target IDGM-MP1302
    Target NameORAI3
    Gene ID93129,269999,309000,712360,607303,101091330,515971,100063559
    Gene Symbol and Synonyms9930124N15,CRACM3,ORAI3,RGD1306538,™EM142C
    Uniprot AccessionQ9BRQ5,Q6AXR8
    Uniprot Entry NameORAI3_HUMAN,ORAI3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000175938
    Target ClassificationN/A

    The target: ORAI3, gene name: ORAI3, also named as ™EM142C. Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.