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Anti-OTOAN/ OTOA/ CT108 monoclonal antibody
Anti-OTOAN/ OTOA/ CT108 antibody for FACS & in-vivo assay
Go to OTOA/OTOA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1304-Ab-1/ GM-Tg-hg-MP1304-Ab-2 | Anti-Human OTOA monoclonal antibody | Human |
| GM-Tg-rg-MP1304-Ab-1/ GM-Tg-rg-MP1304-Ab-2 | Anti-Rat OTOA monoclonal antibody | Rat |
| GM-Tg-mg-MP1304-Ab-1/ GM-Tg-mg-MP1304-Ab-2 | Anti-Mouse OTOA monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1304-Ab-1/ GM-Tg-cynog-MP1304-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OTOA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1304-Ab-1/ GM-Tg-felg-MP1304-Ab-2 | Anti-Feline OTOA monoclonal antibody | Feline |
| GM-Tg-cang-MP1304-Ab-1/ GM-Tg-cang-MP1304-Ab-2 | Anti-Canine OTOA monoclonal antibody | Canine |
| GM-Tg-bovg-MP1304-Ab-1/ GM-Tg-bovg-MP1304-Ab-2 | Anti-Bovine OTOA monoclonal antibody | Bovine |
| GM-Tg-equg-MP1304-Ab-1/ GM-Tg-equg-MP1304-Ab-2 | Anti-Equine OTOA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1304-Ab-1/ GM-Tg-hg-MP1304-Ab-2; GM-Tg-rg-MP1304-Ab-1/ GM-Tg-rg-MP1304-Ab-2; GM-Tg-mg-MP1304-Ab-1/ GM-Tg-mg-MP1304-Ab-2; GM-Tg-cynog-MP1304-Ab-1/ GM-Tg-cynog-MP1304-Ab-2; GM-Tg-felg-MP1304-Ab-1/ GM-Tg-felg-MP1304-Ab-2; GM-Tg-cang-MP1304-Ab-1/ GM-Tg-cang-MP1304-Ab-2; GM-Tg-bovg-MP1304-Ab-1/ GM-Tg-bovg-MP1304-Ab-2; GM-Tg-equg-MP1304-Ab-1/ GM-Tg-equg-MP1304-Ab-2 |
| Products Name | Anti-OTOA monoclonal antibody |
| Format | mab |
| Target Name | OTOA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OTOA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species OTOAN/ OTOA/ CT108 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1304 |
| Target Name | OTOA |
| Gene ID | 146183,246190,499260,699600,608655,101100271,617718,100068851 |
| Gene Symbol and Synonyms | CT108,DFNB22,OTOA,RGD1562741 |
| Uniprot Accession | Q7RTW8 |
| Uniprot Entry Name | OTOAN_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000155719 |
| Target Classification | N/A |
The target: OTOA, gene name: OTOA, also named as CT108, DFNB22. The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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