Anti-P2RX2/ DFNA41/ P2X2 monoclonal antibody

Anti-P2RX2/ DFNA41/ P2X2 antibody for FACS & in-vivo assay

Target products collectionGo to P2RX2/P2RX2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1307-Ab-1/ GM-Tg-hg-MP1307-Ab-2Anti-Human P2RX2 monoclonal antibodyHuman
GM-Tg-rg-MP1307-Ab-1/ GM-Tg-rg-MP1307-Ab-2Anti-Rat P2RX2 monoclonal antibodyRat
GM-Tg-mg-MP1307-Ab-1/ GM-Tg-mg-MP1307-Ab-2Anti-Mouse P2RX2 monoclonal antibodyMouse
GM-Tg-cynog-MP1307-Ab-1/ GM-Tg-cynog-MP1307-Ab-2Anti-Cynomolgus/ Rhesus macaque P2RX2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1307-Ab-1/ GM-Tg-felg-MP1307-Ab-2Anti-Feline P2RX2 monoclonal antibodyFeline
GM-Tg-cang-MP1307-Ab-1/ GM-Tg-cang-MP1307-Ab-2Anti-Canine P2RX2 monoclonal antibodyCanine
GM-Tg-bovg-MP1307-Ab-1/ GM-Tg-bovg-MP1307-Ab-2Anti-Bovine P2RX2 monoclonal antibodyBovine
GM-Tg-equg-MP1307-Ab-1/ GM-Tg-equg-MP1307-Ab-2Anti-Equine P2RX2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1307-Ab-1/ GM-Tg-hg-MP1307-Ab-2; GM-Tg-rg-MP1307-Ab-1/ GM-Tg-rg-MP1307-Ab-2;
GM-Tg-mg-MP1307-Ab-1/ GM-Tg-mg-MP1307-Ab-2; GM-Tg-cynog-MP1307-Ab-1/ GM-Tg-cynog-MP1307-Ab-2;
GM-Tg-felg-MP1307-Ab-1/ GM-Tg-felg-MP1307-Ab-2; GM-Tg-cang-MP1307-Ab-1/ GM-Tg-cang-MP1307-Ab-2;
GM-Tg-bovg-MP1307-Ab-1/ GM-Tg-bovg-MP1307-Ab-2; GM-Tg-equg-MP1307-Ab-1/ GM-Tg-equg-MP1307-Ab-2
Products NameAnti-P2RX2 monoclonal antibody
Formatmab
Target NameP2RX2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-P2RX2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species P2RX2/ DFNA41/ P2X2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm004229mouse P2rx2 Lentivirus plasmid
    ORF Viral VectorvGMLPm004229mouse P2rx2 Lentivirus particle


    Target information

    Target IDGM-MP1307
    Target NameP2RX2
    Gene ID22953,231602,114115,693390,448781,751616,527499,100061704
    Gene Symbol and SynonymsDFNA41,P2RX2,P2X2,P2X2a
    Uniprot AccessionQ9UBL9,P49653
    Uniprot Entry NameP2RX2_HUMAN,P2RX2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000187848
    Target ClassificationN/A

    The target: P2RX2, gene name: P2RX2, also named as DFNA41, P2X2. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.