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Anti-P2RX6/ P2RXL1/ P2X6 monoclonal antibody
Anti-P2RX6/ P2RXL1/ P2X6 antibody for FACS & in-vivo assay
Go to P2RX6/P2RX6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1309-Ab-1/ GM-Tg-hg-MP1309-Ab-2 | Anti-Human P2RX6 monoclonal antibody | Human |
| GM-Tg-rg-MP1309-Ab-1/ GM-Tg-rg-MP1309-Ab-2 | Anti-Rat P2RX6 monoclonal antibody | Rat |
| GM-Tg-mg-MP1309-Ab-1/ GM-Tg-mg-MP1309-Ab-2 | Anti-Mouse P2RX6 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1309-Ab-1/ GM-Tg-cynog-MP1309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque P2RX6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1309-Ab-1/ GM-Tg-felg-MP1309-Ab-2 | Anti-Feline P2RX6 monoclonal antibody | Feline |
| GM-Tg-cang-MP1309-Ab-1/ GM-Tg-cang-MP1309-Ab-2 | Anti-Canine P2RX6 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1309-Ab-1/ GM-Tg-bovg-MP1309-Ab-2 | Anti-Bovine P2RX6 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1309-Ab-1/ GM-Tg-equg-MP1309-Ab-2 | Anti-Equine P2RX6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1309-Ab-1/ GM-Tg-hg-MP1309-Ab-2; GM-Tg-rg-MP1309-Ab-1/ GM-Tg-rg-MP1309-Ab-2; GM-Tg-mg-MP1309-Ab-1/ GM-Tg-mg-MP1309-Ab-2; GM-Tg-cynog-MP1309-Ab-1/ GM-Tg-cynog-MP1309-Ab-2; GM-Tg-felg-MP1309-Ab-1/ GM-Tg-felg-MP1309-Ab-2; GM-Tg-cang-MP1309-Ab-1/ GM-Tg-cang-MP1309-Ab-2; GM-Tg-bovg-MP1309-Ab-1/ GM-Tg-bovg-MP1309-Ab-2; GM-Tg-equg-MP1309-Ab-1/ GM-Tg-equg-MP1309-Ab-2 |
| Products Name | Anti-P2RX6 monoclonal antibody |
| Format | mab |
| Target Name | P2RX6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-P2RX6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species P2RX6/ P2RXL1/ P2X6 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1309 |
| Target Name | P2RX6 |
| Gene ID | 9127,18440,25041,695841,618262,100051842 |
| Gene Symbol and Synonyms | P2RX6,P2RXL1,P2X6,P2XM,Rnap2x6 |
| Uniprot Accession | O15547,P51579 |
| Uniprot Entry Name | P2RX6_HUMAN,P2RX6_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000099957 |
| Target Classification | N/A |
The target: P2RX6, gene name: P2RX6, also named as P2RXL1, P2X6, P2XM. The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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