Anti-PANX2/ PX2/ hPANX2 monoclonal antibody

Anti-PANX2/ PX2/ hPANX2 antibody for FACS & in-vivo assay

Target products collectionGo to PANX2/PANX2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1313-Ab-1/ GM-Tg-hg-MP1313-Ab-2Anti-Human PANX2 monoclonal antibodyHuman
GM-Tg-rg-MP1313-Ab-1/ GM-Tg-rg-MP1313-Ab-2Anti-Rat PANX2 monoclonal antibodyRat
GM-Tg-mg-MP1313-Ab-1/ GM-Tg-mg-MP1313-Ab-2Anti-Mouse PANX2 monoclonal antibodyMouse
GM-Tg-cynog-MP1313-Ab-1/ GM-Tg-cynog-MP1313-Ab-2Anti-Cynomolgus/ Rhesus macaque PANX2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1313-Ab-1/ GM-Tg-felg-MP1313-Ab-2Anti-Feline PANX2 monoclonal antibodyFeline
GM-Tg-cang-MP1313-Ab-1/ GM-Tg-cang-MP1313-Ab-2Anti-Canine PANX2 monoclonal antibodyCanine
GM-Tg-bovg-MP1313-Ab-1/ GM-Tg-bovg-MP1313-Ab-2Anti-Bovine PANX2 monoclonal antibodyBovine
GM-Tg-equg-MP1313-Ab-1/ GM-Tg-equg-MP1313-Ab-2Anti-Equine PANX2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1313-Ab-1/ GM-Tg-hg-MP1313-Ab-2; GM-Tg-rg-MP1313-Ab-1/ GM-Tg-rg-MP1313-Ab-2;
GM-Tg-mg-MP1313-Ab-1/ GM-Tg-mg-MP1313-Ab-2; GM-Tg-cynog-MP1313-Ab-1/ GM-Tg-cynog-MP1313-Ab-2;
GM-Tg-felg-MP1313-Ab-1/ GM-Tg-felg-MP1313-Ab-2; GM-Tg-cang-MP1313-Ab-1/ GM-Tg-cang-MP1313-Ab-2;
GM-Tg-bovg-MP1313-Ab-1/ GM-Tg-bovg-MP1313-Ab-2; GM-Tg-equg-MP1313-Ab-1/ GM-Tg-equg-MP1313-Ab-2
Products NameAnti-PANX2 monoclonal antibody
Formatmab
Target NamePANX2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PANX2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PANX2/ PX2/ hPANX2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1313
    Target NamePANX2
    Gene ID56666,406218,362979,720613,481195,101101322,539070,100056108
    Gene Symbol and SynonymshPANX2,PANX2,PX2
    Uniprot AccessionQ96RD6,P60571
    Uniprot Entry NamePANX2_HUMAN,PANX2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000073150
    Target ClassificationN/A

    The target: PANX2, gene name: PANX2, also named as PX2, hPANX2. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.