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Anti-PCD12/ PCDH12/ VE-cadherin-2 monoclonal antibody
Anti-PCD12/ PCDH12/ VE-cadherin-2 antibody for FACS & in-vivo assay
Go to PCDH12/PCDH12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1328-Ab-1/ GM-Tg-hg-MP1328-Ab-2 | Anti-Human PCDH12 monoclonal antibody | Human |
| GM-Tg-rg-MP1328-Ab-1/ GM-Tg-rg-MP1328-Ab-2 | Anti-Rat PCDH12 monoclonal antibody | Rat |
| GM-Tg-mg-MP1328-Ab-1/ GM-Tg-mg-MP1328-Ab-2 | Anti-Mouse PCDH12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1328-Ab-1/ GM-Tg-cynog-MP1328-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCDH12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1328-Ab-1/ GM-Tg-felg-MP1328-Ab-2 | Anti-Feline PCDH12 monoclonal antibody | Feline |
| GM-Tg-cang-MP1328-Ab-1/ GM-Tg-cang-MP1328-Ab-2 | Anti-Canine PCDH12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1328-Ab-1/ GM-Tg-bovg-MP1328-Ab-2 | Anti-Bovine PCDH12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1328-Ab-1/ GM-Tg-equg-MP1328-Ab-2 | Anti-Equine PCDH12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1328-Ab-1/ GM-Tg-hg-MP1328-Ab-2; GM-Tg-rg-MP1328-Ab-1/ GM-Tg-rg-MP1328-Ab-2; GM-Tg-mg-MP1328-Ab-1/ GM-Tg-mg-MP1328-Ab-2; GM-Tg-cynog-MP1328-Ab-1/ GM-Tg-cynog-MP1328-Ab-2; GM-Tg-felg-MP1328-Ab-1/ GM-Tg-felg-MP1328-Ab-2; GM-Tg-cang-MP1328-Ab-1/ GM-Tg-cang-MP1328-Ab-2; GM-Tg-bovg-MP1328-Ab-1/ GM-Tg-bovg-MP1328-Ab-2; GM-Tg-equg-MP1328-Ab-1/ GM-Tg-equg-MP1328-Ab-2 |
| Products Name | Anti-PCDH12 monoclonal antibody |
| Format | mab |
| Target Name | PCDH12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCDH12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PCD12/ PCDH12/ VE-cadherin-2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1328 |
| Target Name | PCDH12 |
| Gene ID | 51294,53601,116808,705232,487191,101081023,540115,100072150 |
| Gene Symbol and Synonyms | DMJDS1,PCDH12,Pcdh14,VE-cad-2,VE-cadherin-2,VECAD2 |
| Uniprot Accession | Q9NPG4 |
| Uniprot Entry Name | PCD12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000113555 |
| Target Classification | N/A |
The target: PCDH12, gene name: PCDH12, also named as VE-cadherin-2, VECAD2. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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