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Anti-PCD15/ PCDH15/ CDHR15 monoclonal antibody
Anti-PCD15/ PCDH15/ CDHR15 antibody for FACS & in-vivo assay
Go to PCDH15/PCDH15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1329-Ab-1/ GM-Tg-hg-MP1329-Ab-2 | Anti-Human PCDH15 monoclonal antibody | Human |
| GM-Tg-rg-MP1329-Ab-1/ GM-Tg-rg-MP1329-Ab-2 | Anti-Rat PCDH15 monoclonal antibody | Rat |
| GM-Tg-mg-MP1329-Ab-1/ GM-Tg-mg-MP1329-Ab-2 | Anti-Mouse PCDH15 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1329-Ab-1/ GM-Tg-cynog-MP1329-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCDH15 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1329-Ab-1/ GM-Tg-felg-MP1329-Ab-2 | Anti-Feline PCDH15 monoclonal antibody | Feline |
| GM-Tg-cang-MP1329-Ab-1/ GM-Tg-cang-MP1329-Ab-2 | Anti-Canine PCDH15 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1329-Ab-1/ GM-Tg-bovg-MP1329-Ab-2 | Anti-Bovine PCDH15 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1329-Ab-1/ GM-Tg-equg-MP1329-Ab-2 | Anti-Equine PCDH15 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1329-Ab-1/ GM-Tg-hg-MP1329-Ab-2; GM-Tg-rg-MP1329-Ab-1/ GM-Tg-rg-MP1329-Ab-2; GM-Tg-mg-MP1329-Ab-1/ GM-Tg-mg-MP1329-Ab-2; GM-Tg-cynog-MP1329-Ab-1/ GM-Tg-cynog-MP1329-Ab-2; GM-Tg-felg-MP1329-Ab-1/ GM-Tg-felg-MP1329-Ab-2; GM-Tg-cang-MP1329-Ab-1/ GM-Tg-cang-MP1329-Ab-2; GM-Tg-bovg-MP1329-Ab-1/ GM-Tg-bovg-MP1329-Ab-2; GM-Tg-equg-MP1329-Ab-1/ GM-Tg-equg-MP1329-Ab-2 |
| Products Name | Anti-PCDH15 monoclonal antibody |
| Format | mab |
| Target Name | PCDH15 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCDH15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PCD15/ PCDH15/ CDHR15 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1329 |
| Target Name | PCDH15 |
| Gene ID | 65217,11994,690865,702413,609280,101088616,100140108,100071973 |
| Gene Symbol and Synonyms | av,CDHR15,DFNB23,Gm9815,nmf19,PCDH15,roda,USH1F |
| Uniprot Accession | Q96QU1 |
| Uniprot Entry Name | PCD15_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000150275 |
| Target Classification | N/A |
The target: PCDH15, gene name: PCDH15, also named as CDHR15, DFNB23, USH1F. This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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