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Anti-PCDB2/ PCDHB2/ PCDH-BETA2 monoclonal antibody
Anti-PCDB2/ PCDHB2/ PCDH-BETA2 antibody for FACS & in-vivo assay
Go to PCDHB2/PCDHB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1344-Ab-1/ GM-Tg-hg-MP1344-Ab-2 | Anti-Human PCDHB2 monoclonal antibody | Human |
| GM-Tg-rg-MP1344-Ab-1/ GM-Tg-rg-MP1344-Ab-2 | Anti-Rat PCDHB2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1344-Ab-1/ GM-Tg-mg-MP1344-Ab-2 | Anti-Mouse PCDHB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1344-Ab-1/ GM-Tg-cynog-MP1344-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCDHB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1344-Ab-1/ GM-Tg-felg-MP1344-Ab-2 | Anti-Feline PCDHB2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1344-Ab-1/ GM-Tg-cang-MP1344-Ab-2 | Anti-Canine PCDHB2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1344-Ab-1/ GM-Tg-bovg-MP1344-Ab-2 | Anti-Bovine PCDHB2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1344-Ab-1/ GM-Tg-equg-MP1344-Ab-2 | Anti-Equine PCDHB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1344-Ab-1/ GM-Tg-hg-MP1344-Ab-2; GM-Tg-rg-MP1344-Ab-1/ GM-Tg-rg-MP1344-Ab-2; GM-Tg-mg-MP1344-Ab-1/ GM-Tg-mg-MP1344-Ab-2; GM-Tg-cynog-MP1344-Ab-1/ GM-Tg-cynog-MP1344-Ab-2; GM-Tg-felg-MP1344-Ab-1/ GM-Tg-felg-MP1344-Ab-2; GM-Tg-cang-MP1344-Ab-1/ GM-Tg-cang-MP1344-Ab-2; GM-Tg-bovg-MP1344-Ab-1/ GM-Tg-bovg-MP1344-Ab-2; GM-Tg-equg-MP1344-Ab-1/ GM-Tg-equg-MP1344-Ab-2 |
| Products Name | Anti-PCDHB2 monoclonal antibody |
| Format | mab |
| Target Name | PCDHB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCDHB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PCDB2/ PCDHB2/ PCDH-BETA2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1344 |
| Target Name | PCDHB2 |
| Gene ID | 56133,93873,498843,699623,101093742 |
| Gene Symbol and Synonyms | PCDH-BETA2,PCDHB2,PcdhbB,RGD1563132 |
| Uniprot Accession | Q9Y5E7 |
| Uniprot Entry Name | PCDB2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000112852 |
| Target Classification | N/A |
The target: PCDHB2, gene name: PCDHB2, also named as PCDH-BETA2. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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