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Anti-PCDGK/ PCDHGC3/ PC43 monoclonal antibody
Anti-PCDGK/ PCDHGC3/ PC43 antibody for FACS & in-vivo assay
Go to PCDHGC3/PCDHGC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1354-Ab-1/ GM-Tg-hg-MP1354-Ab-2 | Anti-Human PCDHGC3 monoclonal antibody | Human |
| GM-Tg-rg-MP1354-Ab-1/ GM-Tg-rg-MP1354-Ab-2 | Anti-Rat PCDHGC3 monoclonal antibody | Rat |
| GM-Tg-mg-MP1354-Ab-1/ GM-Tg-mg-MP1354-Ab-2 | Anti-Mouse PCDHGC3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1354-Ab-1/ GM-Tg-cynog-MP1354-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCDHGC3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1354-Ab-1/ GM-Tg-felg-MP1354-Ab-2 | Anti-Feline PCDHGC3 monoclonal antibody | Feline |
| GM-Tg-cang-MP1354-Ab-1/ GM-Tg-cang-MP1354-Ab-2 | Anti-Canine PCDHGC3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1354-Ab-1/ GM-Tg-bovg-MP1354-Ab-2 | Anti-Bovine PCDHGC3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1354-Ab-1/ GM-Tg-equg-MP1354-Ab-2 | Anti-Equine PCDHGC3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1354-Ab-1/ GM-Tg-hg-MP1354-Ab-2; GM-Tg-rg-MP1354-Ab-1/ GM-Tg-rg-MP1354-Ab-2; GM-Tg-mg-MP1354-Ab-1/ GM-Tg-mg-MP1354-Ab-2; GM-Tg-cynog-MP1354-Ab-1/ GM-Tg-cynog-MP1354-Ab-2; GM-Tg-felg-MP1354-Ab-1/ GM-Tg-felg-MP1354-Ab-2; GM-Tg-cang-MP1354-Ab-1/ GM-Tg-cang-MP1354-Ab-2; GM-Tg-bovg-MP1354-Ab-1/ GM-Tg-bovg-MP1354-Ab-2; GM-Tg-equg-MP1354-Ab-1/ GM-Tg-equg-MP1354-Ab-2 |
| Products Name | Anti-PCDHGC3 monoclonal antibody |
| Format | mab |
| Target Name | PCDHGC3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCDHGC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PCDGK/ PCDHGC3/ PC43 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1354 |
| Target Name | PCDHGC3 |
| Gene ID | 5098,93706,114678923,100125301 |
| Gene Symbol and Synonyms | PC43,PCDH-GAMMA-C3,PCDH2,PCDHGC3 |
| Uniprot Accession | Q9UN70 |
| Uniprot Entry Name | PCDGK_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000240184 |
| Target Classification | N/A |
The target: PCDHGC3, gene name: PCDHGC3, also named as PC43, PCDH-GAMMA-C3, PCDH2. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
