Anti-PDIA6/ ERP5/ P5 monoclonal antibody

Anti-PDIA6/ ERP5/ P5 antibody for FACS & in-vivo assay

Target products collectionGo to PDIA6/PDIA6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1358-Ab-1/ GM-Tg-hg-MP1358-Ab-2Anti-Human PDIA6 monoclonal antibodyHuman
GM-Tg-rg-MP1358-Ab-1/ GM-Tg-rg-MP1358-Ab-2Anti-Rat PDIA6 monoclonal antibodyRat
GM-Tg-mg-MP1358-Ab-1/ GM-Tg-mg-MP1358-Ab-2Anti-Mouse PDIA6 monoclonal antibodyMouse
GM-Tg-cynog-MP1358-Ab-1/ GM-Tg-cynog-MP1358-Ab-2Anti-Cynomolgus/ Rhesus macaque PDIA6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1358-Ab-1/ GM-Tg-felg-MP1358-Ab-2Anti-Feline PDIA6 monoclonal antibodyFeline
GM-Tg-cang-MP1358-Ab-1/ GM-Tg-cang-MP1358-Ab-2Anti-Canine PDIA6 monoclonal antibodyCanine
GM-Tg-bovg-MP1358-Ab-1/ GM-Tg-bovg-MP1358-Ab-2Anti-Bovine PDIA6 monoclonal antibodyBovine
GM-Tg-equg-MP1358-Ab-1/ GM-Tg-equg-MP1358-Ab-2Anti-Equine PDIA6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1358-Ab-1/ GM-Tg-hg-MP1358-Ab-2; GM-Tg-rg-MP1358-Ab-1/ GM-Tg-rg-MP1358-Ab-2;
GM-Tg-mg-MP1358-Ab-1/ GM-Tg-mg-MP1358-Ab-2; GM-Tg-cynog-MP1358-Ab-1/ GM-Tg-cynog-MP1358-Ab-2;
GM-Tg-felg-MP1358-Ab-1/ GM-Tg-felg-MP1358-Ab-2; GM-Tg-cang-MP1358-Ab-1/ GM-Tg-cang-MP1358-Ab-2;
GM-Tg-bovg-MP1358-Ab-1/ GM-Tg-bovg-MP1358-Ab-2; GM-Tg-equg-MP1358-Ab-1/ GM-Tg-equg-MP1358-Ab-2
Products NameAnti-PDIA6 monoclonal antibody
Formatmab
Target NamePDIA6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PDIA6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PDIA6/ ERP5/ P5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1358
    Target NamePDIA6
    Gene ID10130,71853,286906,706781,475668,101095249,613927,100072358
    Gene Symbol and Synonyms1700015E05Rik,CaBP1,CaBP5,ERP5,P5,PDIA6,TXNDC7
    Uniprot AccessionQ15084,Q63081
    Uniprot Entry NamePDIA6_HUMAN,PDIA6_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000143870
    Target ClassificationN/A

    The target: PDIA6, gene name: PDIA6, also named as ERP5, P5, TXNDC7. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.