Anti-PIEZ1/ PIEZO1/ DHS monoclonal antibody

Anti-PIEZ1/ PIEZO1/ DHS antibody for FACS & in-vivo assay

Target products collectionGo to PIEZO1/PIEZO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1365-Ab-1/ GM-Tg-hg-MP1365-Ab-2Anti-Human PIEZO1 monoclonal antibodyHuman
GM-Tg-rg-MP1365-Ab-1/ GM-Tg-rg-MP1365-Ab-2Anti-Rat PIEZO1 monoclonal antibodyRat
GM-Tg-mg-MP1365-Ab-1/ GM-Tg-mg-MP1365-Ab-2Anti-Mouse PIEZO1 monoclonal antibodyMouse
GM-Tg-cynog-MP1365-Ab-1/ GM-Tg-cynog-MP1365-Ab-2Anti-Cynomolgus/ Rhesus macaque PIEZO1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1365-Ab-1/ GM-Tg-felg-MP1365-Ab-2Anti-Feline PIEZO1 monoclonal antibodyFeline
GM-Tg-cang-MP1365-Ab-1/ GM-Tg-cang-MP1365-Ab-2Anti-Canine PIEZO1 monoclonal antibodyCanine
GM-Tg-bovg-MP1365-Ab-1/ GM-Tg-bovg-MP1365-Ab-2Anti-Bovine PIEZO1 monoclonal antibodyBovine
GM-Tg-equg-MP1365-Ab-1/ GM-Tg-equg-MP1365-Ab-2Anti-Equine PIEZO1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1365-Ab-1/ GM-Tg-hg-MP1365-Ab-2; GM-Tg-rg-MP1365-Ab-1/ GM-Tg-rg-MP1365-Ab-2;
GM-Tg-mg-MP1365-Ab-1/ GM-Tg-mg-MP1365-Ab-2; GM-Tg-cynog-MP1365-Ab-1/ GM-Tg-cynog-MP1365-Ab-2;
GM-Tg-felg-MP1365-Ab-1/ GM-Tg-felg-MP1365-Ab-2; GM-Tg-cang-MP1365-Ab-1/ GM-Tg-cang-MP1365-Ab-2;
GM-Tg-bovg-MP1365-Ab-1/ GM-Tg-bovg-MP1365-Ab-2; GM-Tg-equg-MP1365-Ab-1/ GM-Tg-equg-MP1365-Ab-2
Products NameAnti-PIEZO1 monoclonal antibody
Formatmab
Target NamePIEZO1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PIEZO1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PIEZ1/ PIEZO1/ DHS VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1365
    Target NamePIEZO1
    Gene ID9780,234839,361430,711216,489662,101098421,789183,100050994
    Gene Symbol and Synonyms9630020g22,DHS,ER,FAM38A,LMPH3,LMPHM6,Mib,mKIAA0233,PIEZO1
    Uniprot AccessionQ92508,Q0KL00
    Uniprot Entry NamePIEZ1_HUMAN,PIEZ1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000103335
    Target ClassificationN/A

    The target: PIEZO1, gene name: PIEZO1, also named as DHS, FAM38A, LMPH3, Mib. The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.