Anti-PIGN/ MCAHS/ MCAHS1 monoclonal antibody

Anti-PIGN/ MCAHS/ MCAHS1 antibody for FACS & in-vivo assay

Target products collectionGo to PIGN/PIGN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1367-Ab-1/ GM-Tg-hg-MP1367-Ab-2Anti-Human PIGN monoclonal antibodyHuman
GM-Tg-rg-MP1367-Ab-1/ GM-Tg-rg-MP1367-Ab-2Anti-Rat PIGN monoclonal antibodyRat
GM-Tg-mg-MP1367-Ab-1/ GM-Tg-mg-MP1367-Ab-2Anti-Mouse PIGN monoclonal antibodyMouse
GM-Tg-cynog-MP1367-Ab-1/ GM-Tg-cynog-MP1367-Ab-2Anti-Cynomolgus/ Rhesus macaque PIGN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1367-Ab-1/ GM-Tg-felg-MP1367-Ab-2Anti-Feline PIGN monoclonal antibodyFeline
GM-Tg-cang-MP1367-Ab-1/ GM-Tg-cang-MP1367-Ab-2Anti-Canine PIGN monoclonal antibodyCanine
GM-Tg-bovg-MP1367-Ab-1/ GM-Tg-bovg-MP1367-Ab-2Anti-Bovine PIGN monoclonal antibodyBovine
GM-Tg-equg-MP1367-Ab-1/ GM-Tg-equg-MP1367-Ab-2Anti-Equine PIGN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1367-Ab-1/ GM-Tg-hg-MP1367-Ab-2; GM-Tg-rg-MP1367-Ab-1/ GM-Tg-rg-MP1367-Ab-2;
GM-Tg-mg-MP1367-Ab-1/ GM-Tg-mg-MP1367-Ab-2; GM-Tg-cynog-MP1367-Ab-1/ GM-Tg-cynog-MP1367-Ab-2;
GM-Tg-felg-MP1367-Ab-1/ GM-Tg-felg-MP1367-Ab-2; GM-Tg-cang-MP1367-Ab-1/ GM-Tg-cang-MP1367-Ab-2;
GM-Tg-bovg-MP1367-Ab-1/ GM-Tg-bovg-MP1367-Ab-2; GM-Tg-equg-MP1367-Ab-1/ GM-Tg-equg-MP1367-Ab-2
Products NameAnti-PIGN monoclonal antibody
Formatmab
Target NamePIGN
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PIGN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PIGN/ MCAHS/ MCAHS1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1367
    Target NamePIGN
    Gene ID23556,27392,309051,699219,476182,101082599,525095,100050704
    Gene Symbol and SynonymsGm20308,MCAHS,MCAHS1,MCD4,MDC4,PIG-N,PIGN
    Uniprot AccessionO95427
    Uniprot Entry NamePIGN_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000197563
    Target ClassificationN/A

    The target: PIGN, gene name: PIGN, also named as MCAHS, MCAHS1, MCD4, MDC4, PIG-N. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.