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Anti-PKD1/ PBP/ PC1 monoclonal antibody
Anti-PKD1/ PBP/ PC1 antibody for FACS & in-vivo assay
Go to PKD1/PKD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1374-Ab-1/ GM-Tg-hg-MP1374-Ab-2 | Anti-Human PKD1 monoclonal antibody | Human |
| GM-Tg-rg-MP1374-Ab-1/ GM-Tg-rg-MP1374-Ab-2 | Anti-Rat PKD1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1374-Ab-1/ GM-Tg-mg-MP1374-Ab-2 | Anti-Mouse PKD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1374-Ab-1/ GM-Tg-cynog-MP1374-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PKD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1374-Ab-1/ GM-Tg-felg-MP1374-Ab-2 | Anti-Feline PKD1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1374-Ab-1/ GM-Tg-cang-MP1374-Ab-2 | Anti-Canine PKD1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1374-Ab-1/ GM-Tg-bovg-MP1374-Ab-2 | Anti-Bovine PKD1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1374-Ab-1/ GM-Tg-equg-MP1374-Ab-2 | Anti-Equine PKD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1374-Ab-1/ GM-Tg-hg-MP1374-Ab-2; GM-Tg-rg-MP1374-Ab-1/ GM-Tg-rg-MP1374-Ab-2; GM-Tg-mg-MP1374-Ab-1/ GM-Tg-mg-MP1374-Ab-2; GM-Tg-cynog-MP1374-Ab-1/ GM-Tg-cynog-MP1374-Ab-2; GM-Tg-felg-MP1374-Ab-1/ GM-Tg-felg-MP1374-Ab-2; GM-Tg-cang-MP1374-Ab-1/ GM-Tg-cang-MP1374-Ab-2; GM-Tg-bovg-MP1374-Ab-1/ GM-Tg-bovg-MP1374-Ab-2; GM-Tg-equg-MP1374-Ab-1/ GM-Tg-equg-MP1374-Ab-2 |
| Products Name | Anti-PKD1 monoclonal antibody |
| Format | mab |
| Target Name | PKD1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PKD1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PKD1/ PBP/ PC1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1374 |
| Target Name | PKD1 |
| Gene ID | 5310,18763,24650,694905,606755,100144606,504986,100068126 |
| Gene Symbol and Synonyms | mFLJ00285,PBP,Pc-1,PC1,PKD1,TRPP1 |
| Uniprot Accession | P98161 |
| Uniprot Entry Name | PKD1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000008710 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PKD1, gene name: PKD1, also named as PBP, PC1, Pc-1, TRPP1. This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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