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Anti-PA2G3/ PLA2G3/ GIII-SPLA2 monoclonal antibody
Anti-PA2G3/ PLA2G3/ GIII-SPLA2 antibody for FACS & in-vivo assay
Go to PLA2G3/PLA2G3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1379-Ab-1/ GM-Tg-hg-MP1379-Ab-2 | Anti-Human PLA2G3 monoclonal antibody | Human |
| GM-Tg-rg-MP1379-Ab-1/ GM-Tg-rg-MP1379-Ab-2 | Anti-Rat PLA2G3 monoclonal antibody | Rat |
| GM-Tg-mg-MP1379-Ab-1/ GM-Tg-mg-MP1379-Ab-2 | Anti-Mouse PLA2G3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1379-Ab-1/ GM-Tg-cynog-MP1379-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLA2G3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1379-Ab-1/ GM-Tg-felg-MP1379-Ab-2 | Anti-Feline PLA2G3 monoclonal antibody | Feline |
| GM-Tg-cang-MP1379-Ab-1/ GM-Tg-cang-MP1379-Ab-2 | Anti-Canine PLA2G3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1379-Ab-1/ GM-Tg-bovg-MP1379-Ab-2 | Anti-Bovine PLA2G3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1379-Ab-1/ GM-Tg-equg-MP1379-Ab-2 | Anti-Equine PLA2G3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1379-Ab-1/ GM-Tg-hg-MP1379-Ab-2; GM-Tg-rg-MP1379-Ab-1/ GM-Tg-rg-MP1379-Ab-2; GM-Tg-mg-MP1379-Ab-1/ GM-Tg-mg-MP1379-Ab-2; GM-Tg-cynog-MP1379-Ab-1/ GM-Tg-cynog-MP1379-Ab-2; GM-Tg-felg-MP1379-Ab-1/ GM-Tg-felg-MP1379-Ab-2; GM-Tg-cang-MP1379-Ab-1/ GM-Tg-cang-MP1379-Ab-2; GM-Tg-bovg-MP1379-Ab-1/ GM-Tg-bovg-MP1379-Ab-2; GM-Tg-equg-MP1379-Ab-1/ GM-Tg-equg-MP1379-Ab-2 |
| Products Name | Anti-PLA2G3 monoclonal antibody |
| Format | mab |
| Target Name | PLA2G3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLA2G3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PA2G3/ PLA2G3/ GIII-SPLA2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1379 |
| Target Name | PLA2G3 |
| Gene ID | 50487,237625,289733,718321,486361,101096267,527631,100058509 |
| Gene Symbol and Synonyms | GIII-SPLA2,PLA2G3,sPLA2-III,SPLA2III |
| Uniprot Accession | Q9NZ20,Q1JPB9 |
| Uniprot Entry Name | PA2G3_HUMAN,PA2G3_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100078 |
| Target Classification | N/A |
The target: PLA2G3, gene name: PLA2G3, also named as GIII-SPLA2, SPLA2III, sPLA2-III. This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
