Anti-PLPL2/ PNPLA2/ 1110001C14Rik monoclonal antibody

Anti-PLPL2/ PNPLA2/ 1110001C14Rik antibody for FACS & in-vivo assay

Target products collectionGo to PNPLA2/PNPLA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1396-Ab-1/ GM-Tg-hg-MP1396-Ab-2Anti-Human PNPLA2 monoclonal antibodyHuman
GM-Tg-rg-MP1396-Ab-1/ GM-Tg-rg-MP1396-Ab-2Anti-Rat PNPLA2 monoclonal antibodyRat
GM-Tg-mg-MP1396-Ab-1/ GM-Tg-mg-MP1396-Ab-2Anti-Mouse PNPLA2 monoclonal antibodyMouse
GM-Tg-cynog-MP1396-Ab-1/ GM-Tg-cynog-MP1396-Ab-2Anti-Cynomolgus/ Rhesus macaque PNPLA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1396-Ab-1/ GM-Tg-felg-MP1396-Ab-2Anti-Feline PNPLA2 monoclonal antibodyFeline
GM-Tg-cang-MP1396-Ab-1/ GM-Tg-cang-MP1396-Ab-2Anti-Canine PNPLA2 monoclonal antibodyCanine
GM-Tg-bovg-MP1396-Ab-1/ GM-Tg-bovg-MP1396-Ab-2Anti-Bovine PNPLA2 monoclonal antibodyBovine
GM-Tg-equg-MP1396-Ab-1/ GM-Tg-equg-MP1396-Ab-2Anti-Equine PNPLA2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1396-Ab-1/ GM-Tg-hg-MP1396-Ab-2; GM-Tg-rg-MP1396-Ab-1/ GM-Tg-rg-MP1396-Ab-2;
GM-Tg-mg-MP1396-Ab-1/ GM-Tg-mg-MP1396-Ab-2; GM-Tg-cynog-MP1396-Ab-1/ GM-Tg-cynog-MP1396-Ab-2;
GM-Tg-felg-MP1396-Ab-1/ GM-Tg-felg-MP1396-Ab-2; GM-Tg-cang-MP1396-Ab-1/ GM-Tg-cang-MP1396-Ab-2;
GM-Tg-bovg-MP1396-Ab-1/ GM-Tg-bovg-MP1396-Ab-2; GM-Tg-equg-MP1396-Ab-1/ GM-Tg-equg-MP1396-Ab-2
Products NameAnti-PNPLA2 monoclonal antibody
Formatmab
Target NamePNPLA2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PNPLA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PLPL2/ PNPLA2/ 1110001C14Rik VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm002198mouse Pnpla2 Lentivirus plasmid
    ORF Viral VectorvGMLPm002198mouse Pnpla2 Lentivirus particle


    Target information

    Target IDGM-MP1396
    Target NamePNPLA2
    Gene ID57104,66853,361676,700824,611403,101082263,508493,100146758
    Gene Symbol and Synonyms0610039C21Rik,1110001C14Rik,ATGL,FP17548,iPLA2zeta,PEDF-R,PNPLA2,RGD1309044,TTS-2.2,TTS2
    Uniprot AccessionQ96AD5,P0C548,Q2KI18
    Uniprot Entry NamePLPL2_HUMAN,PLPL2_RAT,PLPL2_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000177666
    Target ClassificationN/A

    The target: PNPLA2, gene name: PNPLA2, also named as 1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta. This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.