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Anti-PODXL/ Gp200/ PC monoclonal antibody
Anti-PODXL/ Gp200/ PC antibody for FACS & in-vivo assay
Go to PODXL/PODXL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1397-Ab-1/ GM-Tg-hg-MP1397-Ab-2 | Anti-Human PODXL monoclonal antibody | Human |
| GM-Tg-rg-MP1397-Ab-1/ GM-Tg-rg-MP1397-Ab-2 | Anti-Rat PODXL monoclonal antibody | Rat |
| GM-Tg-mg-MP1397-Ab-1/ GM-Tg-mg-MP1397-Ab-2 | Anti-Mouse PODXL monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1397-Ab-1/ GM-Tg-cynog-MP1397-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PODXL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1397-Ab-1/ GM-Tg-felg-MP1397-Ab-2 | Anti-Feline PODXL monoclonal antibody | Feline |
| GM-Tg-cang-MP1397-Ab-1/ GM-Tg-cang-MP1397-Ab-2 | Anti-Canine PODXL monoclonal antibody | Canine |
| GM-Tg-bovg-MP1397-Ab-1/ GM-Tg-bovg-MP1397-Ab-2 | Anti-Bovine PODXL monoclonal antibody | Bovine |
| GM-Tg-equg-MP1397-Ab-1/ GM-Tg-equg-MP1397-Ab-2 | Anti-Equine PODXL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1397-Ab-1/ GM-Tg-hg-MP1397-Ab-2; GM-Tg-rg-MP1397-Ab-1/ GM-Tg-rg-MP1397-Ab-2; GM-Tg-mg-MP1397-Ab-1/ GM-Tg-mg-MP1397-Ab-2; GM-Tg-cynog-MP1397-Ab-1/ GM-Tg-cynog-MP1397-Ab-2; GM-Tg-felg-MP1397-Ab-1/ GM-Tg-felg-MP1397-Ab-2; GM-Tg-cang-MP1397-Ab-1/ GM-Tg-cang-MP1397-Ab-2; GM-Tg-bovg-MP1397-Ab-1/ GM-Tg-bovg-MP1397-Ab-2; GM-Tg-equg-MP1397-Ab-1/ GM-Tg-equg-MP1397-Ab-2 |
| Products Name | Anti-PODXL monoclonal antibody |
| Format | mab |
| Target Name | PODXL |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PODXL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PODXL/ Gp200/ PC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001549 | human PODXL Lentivirus particle |
| ORF Viral Vector | pGMLP001549 | human PODXL Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001729 | mouse Podxl Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001729 | mouse Podxl Lentivirus particle |
Target information
| Target ID | GM-MP1397 |
| Target Name | PODXL |
| Gene ID | 5420,27205,192181,704777,482252,101094167,616366,102150200 |
| Gene Symbol and Synonyms | cPCLP1,gp135,Gp200,Ly102,PC,PCLP,PCLP-1,Pclp1,PDX,podocalyxin,PODXL,PODXL1 |
| Uniprot Accession | O00592,Q9WTQ2,Q52S86 |
| Uniprot Entry Name | PODXL_HUMAN,PODXL_RAT,PODXL_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Renal cell carcinoma, Type 2 diabetes mellitus, Pre-eclampsia, Overweight |
| Gene Ensembl | ENSG00000128567 |
| Target Classification | N/A |
The target: PODXL, gene name: PODXL, also named as Gp200, PC, PCLP, PCLP-1. This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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