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Anti-PERF/ PRF1/ HPLH2 monoclonal antibody
Anti-PERF/ PRF1/ HPLH2 antibody for FACS & in-vivo assay
Go to PRF1/PRF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1402-Ab-1/ GM-Tg-hg-MP1402-Ab-2 | Anti-Human PRF1 monoclonal antibody | Human |
| GM-Tg-rg-MP1402-Ab-1/ GM-Tg-rg-MP1402-Ab-2 | Anti-Rat PRF1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1402-Ab-1/ GM-Tg-mg-MP1402-Ab-2 | Anti-Mouse PRF1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1402-Ab-1/ GM-Tg-cynog-MP1402-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRF1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1402-Ab-1/ GM-Tg-felg-MP1402-Ab-2 | Anti-Feline PRF1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1402-Ab-1/ GM-Tg-cang-MP1402-Ab-2 | Anti-Canine PRF1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1402-Ab-1/ GM-Tg-bovg-MP1402-Ab-2 | Anti-Bovine PRF1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1402-Ab-1/ GM-Tg-equg-MP1402-Ab-2 | Anti-Equine PRF1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1402-Ab-1/ GM-Tg-hg-MP1402-Ab-2; GM-Tg-rg-MP1402-Ab-1/ GM-Tg-rg-MP1402-Ab-2; GM-Tg-mg-MP1402-Ab-1/ GM-Tg-mg-MP1402-Ab-2; GM-Tg-cynog-MP1402-Ab-1/ GM-Tg-cynog-MP1402-Ab-2; GM-Tg-felg-MP1402-Ab-1/ GM-Tg-felg-MP1402-Ab-2; GM-Tg-cang-MP1402-Ab-1/ GM-Tg-cang-MP1402-Ab-2; GM-Tg-bovg-MP1402-Ab-1/ GM-Tg-bovg-MP1402-Ab-2; GM-Tg-equg-MP1402-Ab-1/ GM-Tg-equg-MP1402-Ab-2 |
| Products Name | Anti-PRF1 monoclonal antibody |
| Format | mab |
| Target Name | PRF1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PRF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PERF/ PRF1/ HPLH2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002895 | human PRF1 Lentivirus particle |
| ORF Viral Vector | pGMLP002895 | human PRF1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005220 | mouse Prf1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005220 | mouse Prf1 Lentivirus particle |
Target information
| Target ID | GM-MP1402 |
| Target Name | PRF1 |
| Gene ID | 5551,18646,50669,710241,489030,100113473,369025,100072744 |
| Gene Symbol and Synonyms | Cyta,HPLH2,P1,perforin,Pfn,PFP,Prf-1,PRF1,RATCYTA |
| Uniprot Accession | P14222,P35763 |
| Uniprot Entry Name | PERF_HUMAN,PERF_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000180644 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PRF1, gene name: PRF1, also named as HPLH2, P1, PFP. This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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