Anti-PRND/ DOPPEL/ DPL monoclonal antibody

Anti-PRND/ DOPPEL/ DPL antibody for FACS & in-vivo assay

Target products collectionGo to PRND/PRND products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1405-Ab-1/ GM-Tg-hg-MP1405-Ab-2Anti-Human PRND monoclonal antibodyHuman
GM-Tg-rg-MP1405-Ab-1/ GM-Tg-rg-MP1405-Ab-2Anti-Rat PRND monoclonal antibodyRat
GM-Tg-mg-MP1405-Ab-1/ GM-Tg-mg-MP1405-Ab-2Anti-Mouse PRND monoclonal antibodyMouse
GM-Tg-cynog-MP1405-Ab-1/ GM-Tg-cynog-MP1405-Ab-2Anti-Cynomolgus/ Rhesus macaque PRND monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1405-Ab-1/ GM-Tg-felg-MP1405-Ab-2Anti-Feline PRND monoclonal antibodyFeline
GM-Tg-cang-MP1405-Ab-1/ GM-Tg-cang-MP1405-Ab-2Anti-Canine PRND monoclonal antibodyCanine
GM-Tg-bovg-MP1405-Ab-1/ GM-Tg-bovg-MP1405-Ab-2Anti-Bovine PRND monoclonal antibodyBovine
GM-Tg-equg-MP1405-Ab-1/ GM-Tg-equg-MP1405-Ab-2Anti-Equine PRND monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1405-Ab-1/ GM-Tg-hg-MP1405-Ab-2; GM-Tg-rg-MP1405-Ab-1/ GM-Tg-rg-MP1405-Ab-2;
GM-Tg-mg-MP1405-Ab-1/ GM-Tg-mg-MP1405-Ab-2; GM-Tg-cynog-MP1405-Ab-1/ GM-Tg-cynog-MP1405-Ab-2;
GM-Tg-felg-MP1405-Ab-1/ GM-Tg-felg-MP1405-Ab-2; GM-Tg-cang-MP1405-Ab-1/ GM-Tg-cang-MP1405-Ab-2;
GM-Tg-bovg-MP1405-Ab-1/ GM-Tg-bovg-MP1405-Ab-2; GM-Tg-equg-MP1405-Ab-1/ GM-Tg-equg-MP1405-Ab-2
Products NameAnti-PRND monoclonal antibody
Formatmab
Target NamePRND
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PRND benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PRND/ DOPPEL/ DPL VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1405
    Target NamePRND
    Gene ID23627,113910,717883,485782,101087569,281426,100048937
    Gene Symbol and SynonymsdJ1068H6.4,DOPPEL,DPL,PRND,PrPLP
    Uniprot AccessionQ9UKY0,Q9GK16
    Uniprot Entry NamePRND_HUMAN,PRND_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000171864
    Target ClassificationN/A

    The target: PRND, gene name: PRND, also named as DOPPEL, DPL, PrPLP, dJ1068H6.4. This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.