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Anti-PROS/ PROS1/ PS21 monoclonal antibody
Anti-PROS/ PROS1/ PS21 antibody for FACS & in-vivo assay
Go to PROS1/PROS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1407-Ab-1/ GM-Tg-hg-MP1407-Ab-2 | Anti-Human PROS1 monoclonal antibody | Human |
| GM-Tg-rg-MP1407-Ab-1/ GM-Tg-rg-MP1407-Ab-2 | Anti-Rat PROS1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1407-Ab-1/ GM-Tg-mg-MP1407-Ab-2 | Anti-Mouse PROS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1407-Ab-1/ GM-Tg-cynog-MP1407-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PROS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1407-Ab-1/ GM-Tg-felg-MP1407-Ab-2 | Anti-Feline PROS1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1407-Ab-1/ GM-Tg-cang-MP1407-Ab-2 | Anti-Canine PROS1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1407-Ab-1/ GM-Tg-bovg-MP1407-Ab-2 | Anti-Bovine PROS1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1407-Ab-1/ GM-Tg-equg-MP1407-Ab-2 | Anti-Equine PROS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1407-Ab-1/ GM-Tg-hg-MP1407-Ab-2; GM-Tg-rg-MP1407-Ab-1/ GM-Tg-rg-MP1407-Ab-2; GM-Tg-mg-MP1407-Ab-1/ GM-Tg-mg-MP1407-Ab-2; GM-Tg-cynog-MP1407-Ab-1/ GM-Tg-cynog-MP1407-Ab-2; GM-Tg-felg-MP1407-Ab-1/ GM-Tg-felg-MP1407-Ab-2; GM-Tg-cang-MP1407-Ab-1/ GM-Tg-cang-MP1407-Ab-2; GM-Tg-bovg-MP1407-Ab-1/ GM-Tg-bovg-MP1407-Ab-2; GM-Tg-equg-MP1407-Ab-1/ GM-Tg-equg-MP1407-Ab-2 |
| Products Name | Anti-PROS1 monoclonal antibody |
| Format | mab |
| Target Name | PROS1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PROS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PROS/ PROS1/ PS21 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000507 | Human PROS1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000507 | Human PROS1 Adenovirus particle |
Target information
| Target ID | GM-MP1407 |
| Target Name | PROS1 |
| Gene ID | 5627,19128,81750,694845,478529,101085823,282006,100072912 |
| Gene Symbol and Synonyms | PROS,PROS1,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6 |
| Uniprot Accession | P07225,P53813,Q28520,P07224 |
| Uniprot Entry Name | PROS_HUMAN,PROS_MACMU,PROS_RAT,PROS_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000184500 |
| Target Classification | N/A |
The target: PROS1, gene name: PROS1, also named as PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6. This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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