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Anti-PTC1/ PTCH1/ BCNS monoclonal antibody
Anti-PTC1/ PTCH1/ BCNS antibody for FACS & in-vivo assay
Go to PTCH1/PTCH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1421-Ab-1/ GM-Tg-hg-MP1421-Ab-2 | Anti-Human PTCH1 monoclonal antibody | Human |
| GM-Tg-rg-MP1421-Ab-1/ GM-Tg-rg-MP1421-Ab-2 | Anti-Rat PTCH1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1421-Ab-1/ GM-Tg-mg-MP1421-Ab-2 | Anti-Mouse PTCH1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1421-Ab-1/ GM-Tg-cynog-MP1421-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTCH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1421-Ab-1/ GM-Tg-felg-MP1421-Ab-2 | Anti-Feline PTCH1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1421-Ab-1/ GM-Tg-cang-MP1421-Ab-2 | Anti-Canine PTCH1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1421-Ab-1/ GM-Tg-bovg-MP1421-Ab-2 | Anti-Bovine PTCH1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1421-Ab-1/ GM-Tg-equg-MP1421-Ab-2 | Anti-Equine PTCH1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1421-Ab-1/ GM-Tg-hg-MP1421-Ab-2; GM-Tg-rg-MP1421-Ab-1/ GM-Tg-rg-MP1421-Ab-2; GM-Tg-mg-MP1421-Ab-1/ GM-Tg-mg-MP1421-Ab-2; GM-Tg-cynog-MP1421-Ab-1/ GM-Tg-cynog-MP1421-Ab-2; GM-Tg-felg-MP1421-Ab-1/ GM-Tg-felg-MP1421-Ab-2; GM-Tg-cang-MP1421-Ab-1/ GM-Tg-cang-MP1421-Ab-2; GM-Tg-bovg-MP1421-Ab-1/ GM-Tg-bovg-MP1421-Ab-2; GM-Tg-equg-MP1421-Ab-1/ GM-Tg-equg-MP1421-Ab-2 |
| Products Name | Anti-PTCH1 monoclonal antibody |
| Format | mab |
| Target Name | PTCH1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTCH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTC1/ PTCH1/ BCNS VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1421 |
| Target Name | PTCH1 |
| Gene ID | 5727,19206,89830,718751,484137,101085077,520994,100033936 |
| Gene Symbol and Synonyms | A230106A15Rik,BCNS,BCNS1,mes,NBCCS,PTC,PTC1,PTCH,PTCH1,Ptch2,wig |
| Uniprot Accession | Q13635 |
| Uniprot Entry Name | PTC1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000185920 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PTCH1, gene name: PTCH1, also named as BCNS, NBCCS, PTC, PTC1, PTCH. This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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