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Anti-PTPRD/ HPTP/ HPTPD monoclonal antibody
Anti-PTPRD/ HPTP/ HPTPD antibody for FACS & in-vivo assay
Go to PTPRD/PTPRD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1428-Ab-1/ GM-Tg-hg-MP1428-Ab-2 | Anti-Human PTPRD monoclonal antibody | Human |
| GM-Tg-rg-MP1428-Ab-1/ GM-Tg-rg-MP1428-Ab-2 | Anti-Rat PTPRD monoclonal antibody | Rat |
| GM-Tg-mg-MP1428-Ab-1/ GM-Tg-mg-MP1428-Ab-2 | Anti-Mouse PTPRD monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1428-Ab-1/ GM-Tg-cynog-MP1428-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPRD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1428-Ab-1/ GM-Tg-felg-MP1428-Ab-2 | Anti-Feline PTPRD monoclonal antibody | Feline |
| GM-Tg-cang-MP1428-Ab-1/ GM-Tg-cang-MP1428-Ab-2 | Anti-Canine PTPRD monoclonal antibody | Canine |
| GM-Tg-bovg-MP1428-Ab-1/ GM-Tg-bovg-MP1428-Ab-2 | Anti-Bovine PTPRD monoclonal antibody | Bovine |
| GM-Tg-equg-MP1428-Ab-1/ GM-Tg-equg-MP1428-Ab-2 | Anti-Equine PTPRD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1428-Ab-1/ GM-Tg-hg-MP1428-Ab-2; GM-Tg-rg-MP1428-Ab-1/ GM-Tg-rg-MP1428-Ab-2; GM-Tg-mg-MP1428-Ab-1/ GM-Tg-mg-MP1428-Ab-2; GM-Tg-cynog-MP1428-Ab-1/ GM-Tg-cynog-MP1428-Ab-2; GM-Tg-felg-MP1428-Ab-1/ GM-Tg-felg-MP1428-Ab-2; GM-Tg-cang-MP1428-Ab-1/ GM-Tg-cang-MP1428-Ab-2; GM-Tg-bovg-MP1428-Ab-1/ GM-Tg-bovg-MP1428-Ab-2; GM-Tg-equg-MP1428-Ab-1/ GM-Tg-equg-MP1428-Ab-2 |
| Products Name | Anti-PTPRD monoclonal antibody |
| Format | mab |
| Target Name | PTPRD |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTPRD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTPRD/ HPTP/ HPTPD VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1428 |
| Target Name | PTPRD |
| Gene ID | 5789,19266,313278,714954,481538,101094634,532751,100051885 |
| Gene Symbol and Synonyms | 1110002J03Rik,3000002J10Rik,B230219D21Rik,HPTP,HPTPD,HPTPDELTA,PTPD,PTPRD,R-PTP-delta,RPTPDELTA |
| Uniprot Accession | P23468 |
| Uniprot Entry Name | PTPRD_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000153707 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PTPRD, gene name: PTPRD, also named as HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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