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Anti-PTPRN/ IA-2/ IA-2/PTP monoclonal antibody
Anti-PTPRN/ IA-2/ IA-2/PTP antibody for FACS & in-vivo assay
Go to PTPRN/PTPRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1433-Ab-1/ GM-Tg-hg-MP1433-Ab-2 | Anti-Human PTPRN monoclonal antibody | Human |
| GM-Tg-rg-MP1433-Ab-1/ GM-Tg-rg-MP1433-Ab-2 | Anti-Rat PTPRN monoclonal antibody | Rat |
| GM-Tg-mg-MP1433-Ab-1/ GM-Tg-mg-MP1433-Ab-2 | Anti-Mouse PTPRN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1433-Ab-1/ GM-Tg-cynog-MP1433-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPRN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1433-Ab-1/ GM-Tg-felg-MP1433-Ab-2 | Anti-Feline PTPRN monoclonal antibody | Feline |
| GM-Tg-cang-MP1433-Ab-1/ GM-Tg-cang-MP1433-Ab-2 | Anti-Canine PTPRN monoclonal antibody | Canine |
| GM-Tg-bovg-MP1433-Ab-1/ GM-Tg-bovg-MP1433-Ab-2 | Anti-Bovine PTPRN monoclonal antibody | Bovine |
| GM-Tg-equg-MP1433-Ab-1/ GM-Tg-equg-MP1433-Ab-2 | Anti-Equine PTPRN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1433-Ab-1/ GM-Tg-hg-MP1433-Ab-2; GM-Tg-rg-MP1433-Ab-1/ GM-Tg-rg-MP1433-Ab-2; GM-Tg-mg-MP1433-Ab-1/ GM-Tg-mg-MP1433-Ab-2; GM-Tg-cynog-MP1433-Ab-1/ GM-Tg-cynog-MP1433-Ab-2; GM-Tg-felg-MP1433-Ab-1/ GM-Tg-felg-MP1433-Ab-2; GM-Tg-cang-MP1433-Ab-1/ GM-Tg-cang-MP1433-Ab-2; GM-Tg-bovg-MP1433-Ab-1/ GM-Tg-bovg-MP1433-Ab-2; GM-Tg-equg-MP1433-Ab-1/ GM-Tg-equg-MP1433-Ab-2 |
| Products Name | Anti-PTPRN monoclonal antibody |
| Format | mab |
| Target Name | PTPRN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTPRN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTPRN/ IA-2/ IA-2/PTP VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1433 |
| Target Name | PTPRN |
| Gene ID | 5798,19275,116660,702826,478921,101100657,286810,100056346 |
| Gene Symbol and Synonyms | BEM-3,IA-2,IA-2/PTP,IA2,ICA105,ICA512,mIA-A,mKIAA4064,PTP IA-2,PTPLP,PTPRN,R-PTP-N |
| Uniprot Accession | Q16849,Q63259,P56722 |
| Uniprot Entry Name | PTPRN_HUMAN,PTPRN_RAT,PTPRN_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000054356 |
| Target Classification | N/A |
The target: PTPRN, gene name: PTPRN, also named as IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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