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Anti-PTPR2/ PTPRN2/ IA-2beta monoclonal antibody
Anti-PTPR2/ PTPRN2/ IA-2beta antibody for FACS & in-vivo assay
Go to PTPRN2/PTPRN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1434-Ab-1/ GM-Tg-hg-MP1434-Ab-2 | Anti-Human PTPRN2 monoclonal antibody | Human |
| GM-Tg-rg-MP1434-Ab-1/ GM-Tg-rg-MP1434-Ab-2 | Anti-Rat PTPRN2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1434-Ab-1/ GM-Tg-mg-MP1434-Ab-2 | Anti-Mouse PTPRN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1434-Ab-1/ GM-Tg-cynog-MP1434-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPRN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1434-Ab-1/ GM-Tg-felg-MP1434-Ab-2 | Anti-Feline PTPRN2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1434-Ab-1/ GM-Tg-cang-MP1434-Ab-2 | Anti-Canine PTPRN2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1434-Ab-1/ GM-Tg-bovg-MP1434-Ab-2 | Anti-Bovine PTPRN2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1434-Ab-1/ GM-Tg-equg-MP1434-Ab-2 | Anti-Equine PTPRN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1434-Ab-1/ GM-Tg-hg-MP1434-Ab-2; GM-Tg-rg-MP1434-Ab-1/ GM-Tg-rg-MP1434-Ab-2; GM-Tg-mg-MP1434-Ab-1/ GM-Tg-mg-MP1434-Ab-2; GM-Tg-cynog-MP1434-Ab-1/ GM-Tg-cynog-MP1434-Ab-2; GM-Tg-felg-MP1434-Ab-1/ GM-Tg-felg-MP1434-Ab-2; GM-Tg-cang-MP1434-Ab-1/ GM-Tg-cang-MP1434-Ab-2; GM-Tg-bovg-MP1434-Ab-1/ GM-Tg-bovg-MP1434-Ab-2; GM-Tg-equg-MP1434-Ab-1/ GM-Tg-equg-MP1434-Ab-2 |
| Products Name | Anti-PTPRN2 monoclonal antibody |
| Format | mab |
| Target Name | PTPRN2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTPRN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTPR2/ PTPRN2/ IA-2beta VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001719 | human PTPRN2 Lentivirus particle |
| ORF Viral Vector | pGMLP001719 | human PTPRN2 Lentivirus plasmid |
Target information
| Target ID | GM-MP1434 |
| Target Name | PTPRN2 |
| Gene ID | 5799,19276,29714,106997750,482825,101089683,616515,100067294 |
| Gene Symbol and Synonyms | 4930425H11Rik,IA-2beta,IA2beta,IAR,ICAAR,mKIAA0387,phogrin,Phol,PTP-NP,PTPNE6,PTPRN2,PTPRP,R-PTP-N2 |
| Uniprot Accession | Q92932,Q63475 |
| Uniprot Entry Name | PTPR2_HUMAN,PTPR2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000155093 |
| Target Classification | N/A |
The target: PTPRN2, gene name: PTPRN2, also named as IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2. This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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