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Anti-PTPRO/ GLEPP1/ NPHS6 monoclonal antibody
Anti-PTPRO/ GLEPP1/ NPHS6 antibody for FACS & in-vivo assay
Go to PTPRO/PTPRO products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1435-Ab-1/ GM-Tg-hg-MP1435-Ab-2 | Anti-Human PTPRO monoclonal antibody | Human |
| GM-Tg-rg-MP1435-Ab-1/ GM-Tg-rg-MP1435-Ab-2 | Anti-Rat PTPRO monoclonal antibody | Rat |
| GM-Tg-mg-MP1435-Ab-1/ GM-Tg-mg-MP1435-Ab-2 | Anti-Mouse PTPRO monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1435-Ab-1/ GM-Tg-cynog-MP1435-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPRO monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1435-Ab-1/ GM-Tg-felg-MP1435-Ab-2 | Anti-Feline PTPRO monoclonal antibody | Feline |
| GM-Tg-cang-MP1435-Ab-1/ GM-Tg-cang-MP1435-Ab-2 | Anti-Canine PTPRO monoclonal antibody | Canine |
| GM-Tg-bovg-MP1435-Ab-1/ GM-Tg-bovg-MP1435-Ab-2 | Anti-Bovine PTPRO monoclonal antibody | Bovine |
| GM-Tg-equg-MP1435-Ab-1/ GM-Tg-equg-MP1435-Ab-2 | Anti-Equine PTPRO monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1435-Ab-1/ GM-Tg-hg-MP1435-Ab-2; GM-Tg-rg-MP1435-Ab-1/ GM-Tg-rg-MP1435-Ab-2; GM-Tg-mg-MP1435-Ab-1/ GM-Tg-mg-MP1435-Ab-2; GM-Tg-cynog-MP1435-Ab-1/ GM-Tg-cynog-MP1435-Ab-2; GM-Tg-felg-MP1435-Ab-1/ GM-Tg-felg-MP1435-Ab-2; GM-Tg-cang-MP1435-Ab-1/ GM-Tg-cang-MP1435-Ab-2; GM-Tg-bovg-MP1435-Ab-1/ GM-Tg-bovg-MP1435-Ab-2; GM-Tg-equg-MP1435-Ab-1/ GM-Tg-equg-MP1435-Ab-2 |
| Products Name | Anti-PTPRO monoclonal antibody |
| Format | mab |
| Target Name | PTPRO |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTPRO benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTPRO/ GLEPP1/ NPHS6 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1435 |
| Target Name | PTPRO |
| Gene ID | 5800,19277,50677,700811,486664,101098147,541043,100064067 |
| Gene Symbol and Synonyms | D28,GLEPP1,NPHS6,PTP-OC,PTP-U2,PTPBK,Ptpn15,PTPoc,PTPphi,PTPRO,PTPROT,PTPU2,R-PTP-O,RPTP-BK |
| Uniprot Accession | Q16827 |
| Uniprot Entry Name | PTPRO_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000151490 |
| Target Classification | N/A |
The target: PTPRO, gene name: PTPRO, also named as GLEPP1, NPHS6, PTP-OC, PTP-U2T, PTPU2, R-PTP-O, PTPRO. This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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