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Anti-PTPRT/ RPTPrho monoclonal antibody
Anti-PTPRT/ RPTPrho antibody for FACS & in-vivo assay
Go to PTPRT/PTPRT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1437-Ab-1/ GM-Tg-hg-MP1437-Ab-2 | Anti-Human PTPRT monoclonal antibody | Human |
| GM-Tg-rg-MP1437-Ab-1/ GM-Tg-rg-MP1437-Ab-2 | Anti-Rat PTPRT monoclonal antibody | Rat |
| GM-Tg-mg-MP1437-Ab-1/ GM-Tg-mg-MP1437-Ab-2 | Anti-Mouse PTPRT monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1437-Ab-1/ GM-Tg-cynog-MP1437-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPRT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1437-Ab-1/ GM-Tg-felg-MP1437-Ab-2 | Anti-Feline PTPRT monoclonal antibody | Feline |
| GM-Tg-cang-MP1437-Ab-1/ GM-Tg-cang-MP1437-Ab-2 | Anti-Canine PTPRT monoclonal antibody | Canine |
| GM-Tg-bovg-MP1437-Ab-1/ GM-Tg-bovg-MP1437-Ab-2 | Anti-Bovine PTPRT monoclonal antibody | Bovine |
| GM-Tg-equg-MP1437-Ab-1/ GM-Tg-equg-MP1437-Ab-2 | Anti-Equine PTPRT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1437-Ab-1/ GM-Tg-hg-MP1437-Ab-2; GM-Tg-rg-MP1437-Ab-1/ GM-Tg-rg-MP1437-Ab-2; GM-Tg-mg-MP1437-Ab-1/ GM-Tg-mg-MP1437-Ab-2; GM-Tg-cynog-MP1437-Ab-1/ GM-Tg-cynog-MP1437-Ab-2; GM-Tg-felg-MP1437-Ab-1/ GM-Tg-felg-MP1437-Ab-2; GM-Tg-cang-MP1437-Ab-1/ GM-Tg-cang-MP1437-Ab-2; GM-Tg-bovg-MP1437-Ab-1/ GM-Tg-bovg-MP1437-Ab-2; GM-Tg-equg-MP1437-Ab-1/ GM-Tg-equg-MP1437-Ab-2 |
| Products Name | Anti-PTPRT monoclonal antibody |
| Format | mab |
| Target Name | PTPRT |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTPRT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTPRT/ RPTPrho VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1437 |
| Target Name | PTPRT |
| Gene ID | 11122,19281,362263,696796,485878,101091931,524059,100070624 |
| Gene Symbol and Synonyms | mKIAA0283,mRPTPrho,PTPRT,R-PTP-T,RPTP-rfo,RPTP-rho,RPTPmam4,RPTPrho |
| Uniprot Accession | O14522 |
| Uniprot Entry Name | PTPRT_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000196090 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PTPRT, gene name: PTPRT, also named as RPTPrho. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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