Anti-NECT1/ NECTIN1/ CD111 monoclonal antibody

Anti-NECT1/ NECTIN1/ CD111 antibody for FACS & in-vivo assay

Target products collectionGo to NECTIN1/NECTIN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1439-Ab-1/ GM-Tg-hg-MP1439-Ab-2Anti-Human NECTIN1 monoclonal antibodyHuman
GM-Tg-rg-MP1439-Ab-1/ GM-Tg-rg-MP1439-Ab-2Anti-Rat NECTIN1 monoclonal antibodyRat
GM-Tg-mg-MP1439-Ab-1/ GM-Tg-mg-MP1439-Ab-2Anti-Mouse NECTIN1 monoclonal antibodyMouse
GM-Tg-cynog-MP1439-Ab-1/ GM-Tg-cynog-MP1439-Ab-2Anti-Cynomolgus/ Rhesus macaque NECTIN1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1439-Ab-1/ GM-Tg-felg-MP1439-Ab-2Anti-Feline NECTIN1 monoclonal antibodyFeline
GM-Tg-cang-MP1439-Ab-1/ GM-Tg-cang-MP1439-Ab-2Anti-Canine NECTIN1 monoclonal antibodyCanine
GM-Tg-bovg-MP1439-Ab-1/ GM-Tg-bovg-MP1439-Ab-2Anti-Bovine NECTIN1 monoclonal antibodyBovine
GM-Tg-equg-MP1439-Ab-1/ GM-Tg-equg-MP1439-Ab-2Anti-Equine NECTIN1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1439-Ab-1/ GM-Tg-hg-MP1439-Ab-2; GM-Tg-rg-MP1439-Ab-1/ GM-Tg-rg-MP1439-Ab-2;
GM-Tg-mg-MP1439-Ab-1/ GM-Tg-mg-MP1439-Ab-2; GM-Tg-cynog-MP1439-Ab-1/ GM-Tg-cynog-MP1439-Ab-2;
GM-Tg-felg-MP1439-Ab-1/ GM-Tg-felg-MP1439-Ab-2; GM-Tg-cang-MP1439-Ab-1/ GM-Tg-cang-MP1439-Ab-2;
GM-Tg-bovg-MP1439-Ab-1/ GM-Tg-bovg-MP1439-Ab-2; GM-Tg-equg-MP1439-Ab-1/ GM-Tg-equg-MP1439-Ab-2
Products NameAnti-NECTIN1 monoclonal antibody
Formatmab
Target NameNECTIN1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NECTIN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NECT1/ NECTIN1/ CD111 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm002714mouse Nectin1 Lentivirus plasmid
    ORF Viral VectorvGMLPm002714mouse Nectin1 Lentivirus particle


    Target information

    Target IDGM-MP1439
    Target NameNECTIN1
    Gene ID5818,58235,192183,710072,489363,101098252,533492,100063411
    Gene Symbol and SynonymsCD111,CLPED1,ED4,HIgR,HV1S,HVEC,nectin-1,NECTIN1,OFC7,PRR,PRR1,PVRL1,PVRR,PVRR1,SK-12
    Uniprot AccessionQ15223
    Uniprot Entry NameNECT1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000110400
    Target ClassificationN/A

    The target: NECTIN1, gene name: NECTIN1, also named as CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12, nectin-1. This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.