- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-NECT2/ NECTIN2/ CD112 monoclonal antibody
Anti-NECT2/ NECTIN2/ CD112 antibody for FACS & in-vivo assay
Go to NECTIN2/NECTIN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1440-Ab-1/ GM-Tg-hg-MP1440-Ab-2 | Anti-Human NECTIN2 monoclonal antibody | Human |
| GM-Tg-rg-MP1440-Ab-1/ GM-Tg-rg-MP1440-Ab-2 | Anti-Rat NECTIN2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1440-Ab-1/ GM-Tg-mg-MP1440-Ab-2 | Anti-Mouse NECTIN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1440-Ab-1/ GM-Tg-cynog-MP1440-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NECTIN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1440-Ab-1/ GM-Tg-felg-MP1440-Ab-2 | Anti-Feline NECTIN2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1440-Ab-1/ GM-Tg-cang-MP1440-Ab-2 | Anti-Canine NECTIN2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1440-Ab-1/ GM-Tg-bovg-MP1440-Ab-2 | Anti-Bovine NECTIN2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1440-Ab-1/ GM-Tg-equg-MP1440-Ab-2 | Anti-Equine NECTIN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1440-Ab-1/ GM-Tg-hg-MP1440-Ab-2; GM-Tg-rg-MP1440-Ab-1/ GM-Tg-rg-MP1440-Ab-2; GM-Tg-mg-MP1440-Ab-1/ GM-Tg-mg-MP1440-Ab-2; GM-Tg-cynog-MP1440-Ab-1/ GM-Tg-cynog-MP1440-Ab-2; GM-Tg-felg-MP1440-Ab-1/ GM-Tg-felg-MP1440-Ab-2; GM-Tg-cang-MP1440-Ab-1/ GM-Tg-cang-MP1440-Ab-2; GM-Tg-bovg-MP1440-Ab-1/ GM-Tg-bovg-MP1440-Ab-2; GM-Tg-equg-MP1440-Ab-1/ GM-Tg-equg-MP1440-Ab-2 |
| Products Name | Anti-NECTIN2 monoclonal antibody |
| Format | mab |
| Target Name | NECTIN2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NECTIN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NECT2/ NECTIN2/ CD112 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005356 | mouse Nectin2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005356 | mouse Nectin2 Lentivirus particle |
Target information
| Target ID | GM-MP1440 |
| Target Name | NECTIN2 |
| Gene ID | 5819,19294,308417,713229,611060,101087027,505580,100065463 |
| Gene Symbol and Synonyms | CD112,HVEB,MPH,nectin-2,NECTIN2,PRR2,Pvr,PVRL2,PVRR2,Pvs |
| Uniprot Accession | Q92692 |
| Uniprot Entry Name | NECT2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000130202 |
| Target Classification | N/A |
The target: NECTIN2, gene name: NECTIN2, also named as CD112, HVEB, PRR2, PVRL2, PVRR2. This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
