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Anti-RAE1E/ RAET1E/ LETAL monoclonal antibody
Anti-RAE1E/ RAET1E/ LETAL antibody for FACS & in-vivo assay
Go to RAET1E/RAET1E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1447-Ab-1/ GM-Tg-hg-MP1447-Ab-2 | Anti-Human RAET1E monoclonal antibody | Human |
| GM-Tg-rg-MP1447-Ab-1/ GM-Tg-rg-MP1447-Ab-2 | Anti-Rat RAET1E monoclonal antibody | Rat |
| GM-Tg-mg-MP1447-Ab-1/ GM-Tg-mg-MP1447-Ab-2 | Anti-Mouse RAET1E monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1447-Ab-1/ GM-Tg-cynog-MP1447-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAET1E monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1447-Ab-1/ GM-Tg-felg-MP1447-Ab-2 | Anti-Feline RAET1E monoclonal antibody | Feline |
| GM-Tg-cang-MP1447-Ab-1/ GM-Tg-cang-MP1447-Ab-2 | Anti-Canine RAET1E monoclonal antibody | Canine |
| GM-Tg-bovg-MP1447-Ab-1/ GM-Tg-bovg-MP1447-Ab-2 | Anti-Bovine RAET1E monoclonal antibody | Bovine |
| GM-Tg-equg-MP1447-Ab-1/ GM-Tg-equg-MP1447-Ab-2 | Anti-Equine RAET1E monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1447-Ab-1/ GM-Tg-hg-MP1447-Ab-2; GM-Tg-rg-MP1447-Ab-1/ GM-Tg-rg-MP1447-Ab-2; GM-Tg-mg-MP1447-Ab-1/ GM-Tg-mg-MP1447-Ab-2; GM-Tg-cynog-MP1447-Ab-1/ GM-Tg-cynog-MP1447-Ab-2; GM-Tg-felg-MP1447-Ab-1/ GM-Tg-felg-MP1447-Ab-2; GM-Tg-cang-MP1447-Ab-1/ GM-Tg-cang-MP1447-Ab-2; GM-Tg-bovg-MP1447-Ab-1/ GM-Tg-bovg-MP1447-Ab-2; GM-Tg-equg-MP1447-Ab-1/ GM-Tg-equg-MP1447-Ab-2 |
| Products Name | Anti-RAET1E monoclonal antibody |
| Format | mab |
| Target Name | RAET1E |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RAET1E benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RAE1E/ RAET1E/ LETAL VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004907 | human RAET1E Lentivirus particle |
| ORF Viral Vector | pGMLP004907 | human RAET1E Lentivirus plasmid |
Target information
| Target ID | GM-MP1447 |
| Target Name | RAET1E |
| Gene ID | 135250 |
| Gene Symbol and Synonyms | bA350J20.7,LETAL,N2DL-4,NKG2DL4,RAET1E,RAET1E2,RL-4,ULBP4 |
| Uniprot Accession | Q8TD07 |
| Uniprot Entry Name | RAE1E_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000164520 |
| Target Classification | N/A |
The target: RAET1E, gene name: RAET1E, also named as LETAL, N2DL-4, NKG2DL42, RL-4, ULBP4, bA350J20.7, RAET1E. This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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